Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells.
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| Title: | Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells. |
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| Authors: | Tesfamariam YM; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Christensen MH; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Diehl S; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Klein T; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Lingnau JM; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Normann S; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Hagelauer E; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Herbert M; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Reimer S; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Joshi RP; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Engels P; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Pritzl S; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Fontana P; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA., Zillinger T; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.; Department of Biomedicine, Aarhus University, 8000, Aarhus, Denmark., Hartmann G; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Eis-Hübinger A; Institute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Lam MC; Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Walgenbach KJ; Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Meissner F; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany., Wu H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA., Schmidt FI; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany. fschmidt@uni-bonn.de.; Core Facility Nanobodies, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany. fschmidt@uni-bonn.de. |
| Source: | The EMBO journal [EMBO J] 2026 Mar; Vol. 45 (5), pp. 1728-1759. Date of Electronic Publication: 2026 Jan 20. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-025-00690-z |
