Therapeutic targeting of the FSP1-ACSL4 axis reverses cisplatin resistance via ferroptosis induction in drug-tolerant papillary thyroid carcinoma.

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Title: Therapeutic targeting of the FSP1-ACSL4 axis reverses cisplatin resistance via ferroptosis induction in drug-tolerant papillary thyroid carcinoma.
Authors: Yang CY; Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan, Republic of China., Huang CM; Department of Otolaryngology, Taitung Mackay Memorial Hospital, Taitung City, 950408, Taiwan.; Department of Nursing, Tajen University, Pingtung County, Yanpu, 90741, Taiwan., Yasir M; Division of Hematology and Oncology, Taipei Medical University Shuang Ho Hospital, New Taipei City, 23561, Taiwan.; International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Ko CC; Division of Hematology and Oncology, Taipei Medical University Shuang Ho Hospital, New Taipei City, 23561, Taiwan., Yadav VK; Division of Hematology and Oncology, Taipei Medical University Shuang Ho Hospital, New Taipei City, 23561, Taiwan., Liu SC; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical University, No. 325, Sec. 2, Cheng-Gong Road, Neihu District, Taipei, 114, Taiwan, Republic of China. m871435@ndmctsgh.edu.tw.
Source: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2026 Mar; Vol. 283 (3), pp. 1771-1785. Date of Electronic Publication: 2026 Jan 20.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9002937 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-4726 (Electronic) Linking ISSN: 09374477 NLM ISO Abbreviation: Eur Arch Otorhinolaryngol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1434-4726
DOI:10.1007/s00405-025-09975-9