Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells.

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Title: Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells.
Authors: Li Z; Department of Chemistry, Imperial College London, London, UK.; Chemical Glycobiology Laboratory, The Francis Crick Institute, London, UK., Chawla H; Department of Chemistry, Imperial College London, London, UK.; Chemical Glycobiology Laboratory, The Francis Crick Institute, London, UK., Di Vagno L; Chemical Glycobiology Laboratory, The Francis Crick Institute, London, UK.; Proteomics Science Technology Platform, The Francis Crick Institute, London, UK., Ní Cheallaigh A; Lennard-Jones Laboratory, School of Chemical and Physical Sciences and Centre for Glycoscience, Keele University, Keele, UK.; Manchester Institute of Biotechnology and Department of Chemistry, University of Manchester, Manchester, UK., Critcher M; Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research Institute, La Jolla, CA, USA.; Department of Chemistry, Scripps Research Institute, La Jolla, CA, USA., Sammon D; Department of Life Sciences, Imperial College London, London, UK.; Avacta, London, UK., Gonzalez-Rodriguez E; Department of Chemistry, Imperial College London, London, UK.; Chemical Glycobiology Laboratory, The Francis Crick Institute, London, UK., Briggs DC; Signalling and Structural Biology Laboratory, The Francis Crick Institute, London, UK., Chung N; Department of Chemistry, Yale University, New Haven, CT, USA., Chang V; Department of Chemistry, Yale University, New Haven, CT, USA., Mahoney KE; Department of Chemistry, Yale University, New Haven, CT, USA., Cioce A; Department of Chemistry, Imperial College London, London, UK.; Chemical Glycobiology Laboratory, The Francis Crick Institute, London, UK., Bineva-Todd G; Chemical Glycobiology Laboratory, The Francis Crick Institute, London, UK., Wang PY; Glycogenetics, Inc., Taipei, Taiwan., Liu YC; Glycogenetics, Inc., Taipei, Taiwan., Murphy LD; York Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York, York, UK., Chen YH; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; GlycoDisplay ApS, Copenhagen, Denmark., Narimatsu Y; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Miller RL; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Willems LI; York Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York, York, UK., Malaker SA; Department of Chemistry, Yale University, New Haven, CT, USA., Huang ML; Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research Institute, La Jolla, CA, USA.; Department of Chemistry, Scripps Research Institute, La Jolla, CA, USA., Miller GJ; Lennard-Jones Laboratory, School of Chemical and Physical Sciences and Centre for Glycoscience, Keele University, Keele, UK.; Manchester Institute of Biotechnology and Department of Chemistry, University of Manchester, Manchester, UK., Hohenester E; Department of Life Sciences, Imperial College London, London, UK., Schumann B; Department of Chemistry, Imperial College London, London, UK. benjamin.schumann@tu-dresden.de.; Chemical Glycobiology Laboratory, The Francis Crick Institute, London, UK. benjamin.schumann@tu-dresden.de.; Faculty of Chemistry and Food Chemistry, TUD Dresden University of Technology, Dresden, Germany. benjamin.schumann@tu-dresden.de.
Source: Nature chemical biology [Nat Chem Biol] 2026 Apr; Vol. 22 (4), pp. 612-621. Date of Electronic Publication: 2026 Jan 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1552-4469
DOI:10.1038/s41589-025-02113-w