Safety and efficacy of upfront triple therapy including parenteral treprostinil compared to double oral therapy in PAH (TripleTRE): study protocol for a randomised trial.

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Title: Safety and efficacy of upfront triple therapy including parenteral treprostinil compared to double oral therapy in PAH (TripleTRE): study protocol for a randomised trial.
Authors: Sitbon O; Université Paris-Saclay, Inserm UMR_S 999 (HPPIT), Department of Respiratory and Intensive Care Medicine (FHU André Cournand, ERN-LUNG), Hôpital Bicêtre (AP-HP), Le Kremlin Bicêtre, France., Agoston G; Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Csaladorvosi Intezet es Rendelo, Szeged, Hungary., Badagliacca R; Sapienza University of Rome, Dep. Clinical Intern, Anesth. and Cardiovascular Sciences, Rome, Italy., Hajnalka Balint O; Gottsegen National Cardiovascular Centre, Budapest, Hungary., Blanco I; Department of Pulmonary Medicine, Hospital Clinic-IDIBAPS, University of Barcelona; Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Barcelona, Spain., Coman IM; Institutul de Urgență pentru Boli Cardiovasculare, Bucharest, Romania., Ewert R; Klinik und Poliklinik für Innere Medizin B Universitätsmedizin Greifswald, Greifswald, Germany., Halank M; University Hospital Carl Gustav Carus of Technical University Dresden, Division of Pneumology, Medical Department I, Dresden, Germany., Jansa P; 2nd Department of Medicine, Clinical Department of Cardiology and Angiology, General University Hospital, Prague, Czech Republic., Kopeć G; Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases Jagiellonian University Medical College, St John Paul II Hospital in Krakow, Krakow, Poland., Kurzyna M; European Health Centre Otwock, Otwock, Poland., Tenes A; Hospital Universitario Ramón y Cajal, Madrid, Spain., Opitz C; DRK Kliniken Berlin, Berlin, Germany., Plácido R; Heart and Vessels Department, University Hospital ULS Santa Maria, CCUL@RISE, Faculty of Medicine, Lisbon University, Lisbon, Portugal., Přeček J; Department of Internal Medicine I - Cardiology, University Hospital and Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic., Riou M; Nouvel Hôpital Civil, Strasbourg, France., Steringer-Mascherbauer R; Second Department of Medicine, Public Hospital Elisabethinen, Linz, Austria., Țilea I; Department M3-Internal Medicine, Family Medicine Discipline, Faculty of Medicine, University of Medicine and Pharmacy, Tirgu Mures, Romania., Lang IM; Dept of Cardiology, AKH-Vienna, Medical University of Vienna, Vienna, Austria.
Source: ERJ open research [ERJ Open Res] 2026 Jan 19; Vol. 12 (1). Date of Electronic Publication: 2026 Jan 19 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: European Respiratory Society Country of Publication: England NLM ID: 101671641 Publication Model: eCollection Cited Medium: Print ISSN: 2312-0541 (Print) Linking ISSN: 23120541 NLM ISO Abbreviation: ERJ Open Res Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2312-0541
DOI:10.1183/23120541.00458-2025