Safety and efficacy of upfront triple therapy including parenteral treprostinil compared to double oral therapy in PAH (TripleTRE): study protocol for a randomised trial.
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| Title: | Safety and efficacy of upfront triple therapy including parenteral treprostinil compared to double oral therapy in PAH (TripleTRE): study protocol for a randomised trial. |
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| Authors: | Sitbon O; Université Paris-Saclay, Inserm UMR_S 999 (HPPIT), Department of Respiratory and Intensive Care Medicine (FHU André Cournand, ERN-LUNG), Hôpital Bicêtre (AP-HP), Le Kremlin Bicêtre, France., Agoston G; Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Csaladorvosi Intezet es Rendelo, Szeged, Hungary., Badagliacca R; Sapienza University of Rome, Dep. Clinical Intern, Anesth. and Cardiovascular Sciences, Rome, Italy., Hajnalka Balint O; Gottsegen National Cardiovascular Centre, Budapest, Hungary., Blanco I; Department of Pulmonary Medicine, Hospital Clinic-IDIBAPS, University of Barcelona; Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Barcelona, Spain., Coman IM; Institutul de Urgență pentru Boli Cardiovasculare, Bucharest, Romania., Ewert R; Klinik und Poliklinik für Innere Medizin B Universitätsmedizin Greifswald, Greifswald, Germany., Halank M; University Hospital Carl Gustav Carus of Technical University Dresden, Division of Pneumology, Medical Department I, Dresden, Germany., Jansa P; 2nd Department of Medicine, Clinical Department of Cardiology and Angiology, General University Hospital, Prague, Czech Republic., Kopeć G; Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases Jagiellonian University Medical College, St John Paul II Hospital in Krakow, Krakow, Poland., Kurzyna M; European Health Centre Otwock, Otwock, Poland., Tenes A; Hospital Universitario Ramón y Cajal, Madrid, Spain., Opitz C; DRK Kliniken Berlin, Berlin, Germany., Plácido R; Heart and Vessels Department, University Hospital ULS Santa Maria, CCUL@RISE, Faculty of Medicine, Lisbon University, Lisbon, Portugal., Přeček J; Department of Internal Medicine I - Cardiology, University Hospital and Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic., Riou M; Nouvel Hôpital Civil, Strasbourg, France., Steringer-Mascherbauer R; Second Department of Medicine, Public Hospital Elisabethinen, Linz, Austria., Țilea I; Department M3-Internal Medicine, Family Medicine Discipline, Faculty of Medicine, University of Medicine and Pharmacy, Tirgu Mures, Romania., Lang IM; Dept of Cardiology, AKH-Vienna, Medical University of Vienna, Vienna, Austria. |
| Source: | ERJ open research [ERJ Open Res] 2026 Jan 19; Vol. 12 (1). Date of Electronic Publication: 2026 Jan 19 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: European Respiratory Society Country of Publication: England NLM ID: 101671641 Publication Model: eCollection Cited Medium: Print ISSN: 2312-0541 (Print) Linking ISSN: 23120541 NLM ISO Abbreviation: ERJ Open Res Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41561104 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Safety and efficacy of upfront triple therapy including parenteral treprostinil compared to double oral therapy in PAH (TripleTRE): study protocol for a randomised trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Sitbon+O%22">Sitbon O</searchLink>; Université Paris-Saclay, Inserm UMR&#95;S 999 (HPPIT), Department of Respiratory and Intensive Care Medicine (FHU André Cournand, ERN-LUNG), Hôpital Bicêtre (AP-HP), Le Kremlin Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Agoston+G%22">Agoston G</searchLink>; Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Csaladorvosi Intezet es Rendelo, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Badagliacca+R%22">Badagliacca R</searchLink>; Sapienza University of Rome, Dep. Clinical Intern, Anesth. and Cardiovascular Sciences, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Hajnalka+Balint+O%22">Hajnalka Balint O</searchLink>; Gottsegen National Cardiovascular Centre, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Blanco+I%22">Blanco I</searchLink>; Department of Pulmonary Medicine, Hospital Clinic-IDIBAPS, University of Barcelona; Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Coman+IM%22">Coman IM</searchLink>; Institutul de Urgență pentru Boli Cardiovasculare, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Ewert+R%22">Ewert R</searchLink>; Klinik und Poliklinik für Innere Medizin B Universitätsmedizin Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Halank+M%22">Halank M</searchLink>; University Hospital Carl Gustav Carus of Technical University Dresden, Division of Pneumology, Medical Department I, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Jansa+P%22">Jansa P</searchLink>; 2nd Department of Medicine, Clinical Department of Cardiology and Angiology, General University Hospital, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kopeć+G%22">Kopeć G</searchLink>; Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases Jagiellonian University Medical College, St John Paul II Hospital in Krakow, Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Kurzyna+M%22">Kurzyna M</searchLink>; European Health Centre Otwock, Otwock, Poland.<br /><searchLink fieldCode="AU" term="%22Tenes+A%22">Tenes A</searchLink>; Hospital Universitario Ramón y Cajal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Opitz+C%22">Opitz C</searchLink>; DRK Kliniken Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Plácido+R%22">Plácido R</searchLink>; Heart and Vessels Department, University Hospital ULS Santa Maria, CCUL@RISE, Faculty of Medicine, Lisbon University, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Přeček+J%22">Přeček J</searchLink>; Department of Internal Medicine I - Cardiology, University Hospital and Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Riou+M%22">Riou M</searchLink>; Nouvel Hôpital Civil, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Steringer-Mascherbauer+R%22">Steringer-Mascherbauer R</searchLink>; Second Department of Medicine, Public Hospital Elisabethinen, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Țilea+I%22">Țilea I</searchLink>; Department M3-Internal Medicine, Family Medicine Discipline, Faculty of Medicine, University of Medicine and Pharmacy, Tirgu Mures, Romania.<br /><searchLink fieldCode="AU" term="%22Lang+IM%22">Lang IM</searchLink>; Dept of Cardiology, AKH-Vienna, Medical University of Vienna, Vienna, Austria. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101671641%22">ERJ open research</searchLink> [ERJ Open Res] 2026 Jan 19; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Jan 19 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22European+Respiratory+Society%22">European Respiratory Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101671641 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2312-0541 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223120541%22">23120541 </searchLink><i>NLM ISO Abbreviation: </i>ERJ Open Res <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41561104 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1183/23120541.00458-2025 Languages: – Code: eng Text: English Titles: – TitleFull: Safety and efficacy of upfront triple therapy including parenteral treprostinil compared to double oral therapy in PAH (TripleTRE): study protocol for a randomised trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sitbon O – PersonEntity: Name: NameFull: Agoston G – PersonEntity: Name: NameFull: Badagliacca R – PersonEntity: Name: NameFull: Hajnalka Balint O – PersonEntity: Name: NameFull: Blanco I – PersonEntity: Name: NameFull: Coman IM – PersonEntity: Name: NameFull: Ewert R – PersonEntity: Name: NameFull: Halank M – PersonEntity: Name: NameFull: Jansa P – PersonEntity: Name: NameFull: Kopeć G – PersonEntity: Name: NameFull: Kurzyna M – PersonEntity: Name: NameFull: Tenes A – PersonEntity: Name: NameFull: Opitz C – PersonEntity: Name: NameFull: Plácido R – PersonEntity: Name: NameFull: Přeček J – PersonEntity: Name: NameFull: Riou M – PersonEntity: Name: NameFull: Steringer-Mascherbauer R – PersonEntity: Name: NameFull: Țilea I – PersonEntity: Name: NameFull: Lang IM IsPartOfRelationships: – BibEntity: Dates: – D: 19 M: 01 Text: 2026 Jan 19 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 2312-0541 Numbering: – Type: volume Value: 12 – Type: issue Value: 1 Titles: – TitleFull: ERJ open research Type: main |
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