Combining DNA methylation features and clinical characteristics predicts ketamine treatment response for PTSD.

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Title: Combining DNA methylation features and clinical characteristics predicts ketamine treatment response for PTSD.
Authors: Valizadeh A; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA., Roache JD; Department of Psychiatry and Behavioral Sciences, University of Texas at San Antonio, San Antonio, TX, USA.; Research and Development Service, South Texas Veterans Health Care System, San Antonio, TX, USA., Zhang X; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA., Hu Y; Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, MD, USA., Gueorguieva R; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Averill LA; Michael E. DeBakey VA Medical Center, Houston, TX, USA., Ranganathan M; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA., Wang Z; Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA.; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Williamson DE; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.; Durham VA Health Care System, Durham, NC, USA., Shiroma PR; Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, MN, USA.; Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA., Girgenti MJ; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA., Petrakis IL; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA., López-Roca AL; Department of Behavioral Health, Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, Houston, TX, USA.; North Central Federal Clinic, South Texas Veterans Health Care System, San Antonio, TX, USA., Young-McCaughan S; Department of Psychiatry and Behavioral Sciences, University of Texas at San Antonio, San Antonio, TX, USA.; Research and Development Service, South Texas Veterans Health Care System, San Antonio, TX, USA., Keane TM; Behavioral Sciences Division, National Center for PTSD at VA Boston Healthcare System, Boston, MA, USA.; Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA., Peterson AL; Department of Psychiatry and Behavioral Sciences, University of Texas at San Antonio, San Antonio, TX, USA.; Research and Development Service, South Texas Veterans Health Care System, San Antonio, TX, USA.; Department of Psychology, University of Texas at San Antonio, San Antonio, TX, USA., Abdallah CG; Michael E. DeBakey VA Medical Center, Houston, TX, USA.; Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA., Krystal JH; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA., Xu K; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA.
Corporate Authors: Consortium to Alleviate PTSD
Source: IScience [iScience] 2025 Dec 17; Vol. 29 (1), pp. 114445. Date of Electronic Publication: 2025 Dec 17 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-0042
DOI:10.1016/j.isci.2025.114445