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Combining DNA methylation features and clinical characteristics predicts ketamine treatment response for PTSD.

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Title: Combining DNA methylation features and clinical characteristics predicts ketamine treatment response for PTSD.
Authors: Valizadeh A; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA., Roache JD; Department of Psychiatry and Behavioral Sciences, University of Texas at San Antonio, San Antonio, TX, USA.; Research and Development Service, South Texas Veterans Health Care System, San Antonio, TX, USA., Zhang X; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA., Hu Y; Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, MD, USA., Gueorguieva R; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Averill LA; Michael E. DeBakey VA Medical Center, Houston, TX, USA., Ranganathan M; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA., Wang Z; Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA.; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Williamson DE; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.; Durham VA Health Care System, Durham, NC, USA., Shiroma PR; Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, MN, USA.; Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA., Girgenti MJ; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA., Petrakis IL; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA., López-Roca AL; Department of Behavioral Health, Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, Houston, TX, USA.; North Central Federal Clinic, South Texas Veterans Health Care System, San Antonio, TX, USA., Young-McCaughan S; Department of Psychiatry and Behavioral Sciences, University of Texas at San Antonio, San Antonio, TX, USA.; Research and Development Service, South Texas Veterans Health Care System, San Antonio, TX, USA., Keane TM; Behavioral Sciences Division, National Center for PTSD at VA Boston Healthcare System, Boston, MA, USA.; Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA., Peterson AL; Department of Psychiatry and Behavioral Sciences, University of Texas at San Antonio, San Antonio, TX, USA.; Research and Development Service, South Texas Veterans Health Care System, San Antonio, TX, USA.; Department of Psychology, University of Texas at San Antonio, San Antonio, TX, USA., Abdallah CG; Michael E. DeBakey VA Medical Center, Houston, TX, USA.; Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA., Krystal JH; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA., Xu K; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA.
Corporate Authors: Consortium to Alleviate PTSD
Source: IScience [iScience] 2025 Dec 17; Vol. 29 (1), pp. 114445. Date of Electronic Publication: 2025 Dec 17 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Valizadeh+A%22">Valizadeh A</searchLink>; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Roache+JD%22">Roache JD</searchLink>; Department of Psychiatry and Behavioral Sciences, University of Texas at San Antonio, San Antonio, TX, USA.; Research and Development Service, South Texas Veterans Health Care System, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Hu+Y%22">Hu Y</searchLink>; Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gueorguieva+R%22">Gueorguieva R</searchLink>; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Averill+LA%22">Averill LA</searchLink>; Michael E. DeBakey VA Medical Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ranganathan+M%22">Ranganathan M</searchLink>; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA.; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Williamson+DE%22">Williamson DE</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.; Durham VA Health Care System, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Shiroma+PR%22">Shiroma PR</searchLink>; Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, MN, USA.; Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Girgenti+MJ%22">Girgenti MJ</searchLink>; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Petrakis+IL%22">Petrakis IL</searchLink>; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22López-Roca+AL%22">López-Roca AL</searchLink>; Department of Behavioral Health, Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, Houston, TX, USA.; North Central Federal Clinic, South Texas Veterans Health Care System, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Young-McCaughan+S%22">Young-McCaughan S</searchLink>; Department of Psychiatry and Behavioral Sciences, University of Texas at San Antonio, San Antonio, TX, USA.; Research and Development Service, South Texas Veterans Health Care System, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Keane+TM%22">Keane TM</searchLink>; Behavioral Sciences Division, National Center for PTSD at VA Boston Healthcare System, Boston, MA, USA.; Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Peterson+AL%22">Peterson AL</searchLink>; Department of Psychiatry and Behavioral Sciences, University of Texas at San Antonio, San Antonio, TX, USA.; Research and Development Service, South Texas Veterans Health Care System, San Antonio, TX, USA.; Department of Psychology, University of Texas at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Abdallah+CG%22">Abdallah CG</searchLink>; Michael E. DeBakey VA Medical Center, Houston, TX, USA.; Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Krystal+JH%22">Krystal JH</searchLink>; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Xu+K%22">Xu K</searchLink>; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA.
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  Data: <searchLink fieldCode="JN" term="%22101724038%22">IScience</searchLink> [iScience] 2025 Dec 17; Vol. 29 (1), pp. 114445. <i>Date of Electronic Publication: </i>2025 Dec 17 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101724038 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2589-0042 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225890042%22">25890042 </searchLink><i>NLM ISO Abbreviation: </i>iScience <i>Subsets: </i>PubMed not MEDLINE
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