An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models.
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| Title: | An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models. |
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| Authors: | Stromberg ZR; Chemical and Biological Signatures Group, Pacific Northwest National Laboratory, Richland, WA, United States., Silva EE; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States., Johnston SC; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States., Johnson DM; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States., Hall D; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., Adjei EF; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States.; Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, United States., Altin JA; The Translational Genomics Research Institute, Flagstaff, AZ, United States., Abisoye-Ogunniyan A; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., Gollott T; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., He W; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., Jones IKA; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States., Kwilas S; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States., Lund SJ; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States., Mead HL; The Translational Genomics Research Institute, Flagstaff, AZ, United States., Nelson GA; The Translational Genomics Research Institute, Flagstaff, AZ, United States., Ouyang L; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States., Peters SKG; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., Schwedler JL; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States., Trecazzi CZ; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., Turner MW; Chemical and Biological Signatures Group, Pacific Northwest National Laboratory, Richland, WA, United States., Ye C; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, United States., Bradfute SB; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, United States., Fischer NO; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., Hooper JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States., Ladner JT; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States.; Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, United States., Rasley A; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States.; Department of Molecular and Cell Biology, University of California, Merced, CA, United States., Negrete OA; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States. |
| Source: | Frontiers in immunology [Front Immunol] 2026 Jan 05; Vol. 16, pp. 1682418. Date of Electronic Publication: 2026 Jan 05 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2025.1682418 |
