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An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models.

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Title: An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models.
Authors: Stromberg ZR; Chemical and Biological Signatures Group, Pacific Northwest National Laboratory, Richland, WA, United States., Silva EE; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States., Johnston SC; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States., Johnson DM; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States., Hall D; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., Adjei EF; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States.; Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, United States., Altin JA; The Translational Genomics Research Institute, Flagstaff, AZ, United States., Abisoye-Ogunniyan A; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., Gollott T; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., He W; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., Jones IKA; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States., Kwilas S; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States., Lund SJ; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States., Mead HL; The Translational Genomics Research Institute, Flagstaff, AZ, United States., Nelson GA; The Translational Genomics Research Institute, Flagstaff, AZ, United States., Ouyang L; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States., Peters SKG; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., Schwedler JL; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States., Trecazzi CZ; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., Turner MW; Chemical and Biological Signatures Group, Pacific Northwest National Laboratory, Richland, WA, United States., Ye C; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, United States., Bradfute SB; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, United States., Fischer NO; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States., Hooper JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States., Ladner JT; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States.; Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, United States., Rasley A; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States.; Department of Molecular and Cell Biology, University of California, Merced, CA, United States., Negrete OA; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States.
Source: Frontiers in immunology [Front Immunol] 2026 Jan 05; Vol. 16, pp. 1682418. Date of Electronic Publication: 2026 Jan 05 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models.
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  Data: <searchLink fieldCode="AU" term="%22Stromberg+ZR%22">Stromberg ZR</searchLink>; Chemical and Biological Signatures Group, Pacific Northwest National Laboratory, Richland, WA, United States.<br /><searchLink fieldCode="AU" term="%22Silva+EE%22">Silva EE</searchLink>; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22Johnston+SC%22">Johnston SC</searchLink>; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States.<br /><searchLink fieldCode="AU" term="%22Johnson+DM%22">Johnson DM</searchLink>; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22Hall+D%22">Hall D</searchLink>; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22Adjei+EF%22">Adjei EF</searchLink>; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States.; Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, United States.<br /><searchLink fieldCode="AU" term="%22Altin+JA%22">Altin JA</searchLink>; The Translational Genomics Research Institute, Flagstaff, AZ, United States.<br /><searchLink fieldCode="AU" term="%22Abisoye-Ogunniyan+A%22">Abisoye-Ogunniyan A</searchLink>; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22Gollott+T%22">Gollott T</searchLink>; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22He+W%22">He W</searchLink>; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22Jones+IKA%22">Jones IKA</searchLink>; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22Kwilas+S%22">Kwilas S</searchLink>; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States.<br /><searchLink fieldCode="AU" term="%22Lund+SJ%22">Lund SJ</searchLink>; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22Mead+HL%22">Mead HL</searchLink>; The Translational Genomics Research Institute, Flagstaff, AZ, United States.<br /><searchLink fieldCode="AU" term="%22Nelson+GA%22">Nelson GA</searchLink>; The Translational Genomics Research Institute, Flagstaff, AZ, United States.<br /><searchLink fieldCode="AU" term="%22Ouyang+L%22">Ouyang L</searchLink>; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22Peters+SKG%22">Peters SKG</searchLink>; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22Schwedler+JL%22">Schwedler JL</searchLink>; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22Trecazzi+CZ%22">Trecazzi CZ</searchLink>; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22Turner+MW%22">Turner MW</searchLink>; Chemical and Biological Signatures Group, Pacific Northwest National Laboratory, Richland, WA, United States.<br /><searchLink fieldCode="AU" term="%22Ye+C%22">Ye C</searchLink>; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.<br /><searchLink fieldCode="AU" term="%22Bradfute+SB%22">Bradfute SB</searchLink>; Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.<br /><searchLink fieldCode="AU" term="%22Fischer+NO%22">Fischer NO</searchLink>; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States.<br /><searchLink fieldCode="AU" term="%22Hooper+JW%22">Hooper JW</searchLink>; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States.<br /><searchLink fieldCode="AU" term="%22Ladner+JT%22">Ladner JT</searchLink>; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States.; Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, United States.<br /><searchLink fieldCode="AU" term="%22Rasley+A%22">Rasley A</searchLink>; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States.; Department of Molecular and Cell Biology, University of California, Merced, CA, United States.<br /><searchLink fieldCode="AU" term="%22Negrete+OA%22">Negrete OA</searchLink>; Department of Systems Biology, Sandia National Laboratories, Livermore, CA, United States.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Jan 05; Vol. 16, pp. 1682418. <i>Date of Electronic Publication: </i>2026 Jan 05 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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