Latent tuberculosis infection in high TB disease burden countries dysregulates cellular and immunological profiles which is further enhanced with uncontrolled hyperglycemia.

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Title: Latent tuberculosis infection in high TB disease burden countries dysregulates cellular and immunological profiles which is further enhanced with uncontrolled hyperglycemia.
Authors: Masood KI; Department of Pathology and Laboratory Medicine, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan., Yameen M; Department of Pathology and Laboratory Medicine, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan., Ashraf J; Department of Pathology and Laboratory Medicine, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan., Ram N; Department of Medicine, Aga Khan University, Karachi, Pakistan., Saifullah N; Jinnah Postgraduate Medical Center, Karachi, Pakistan., Jamil B; Department of Medicine, Aga Khan University, Karachi, Pakistan., Irfan M; Department of Medicine, Aga Khan University, Karachi, Pakistan., Masood Q; Department of Medicine, Aga Khan University, Karachi, Pakistan., Fatima F; Department of Pathology and Laboratory Medicine, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan., Ajmal A; Department of Pathology and Laboratory Medicine, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan., Dockrell HM; The London School of Hygiene & Tropical Medicine, London, UK., Hussain R; Department of Pathology and Laboratory Medicine, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan., Rottenberg M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden., Cliff JM; Centre for Inflammation Research and Translational Medicine and Department of Biosciences, Brunel University of London, Uxbridge, UK., Hasan Z; Department of Pathology and Laboratory Medicine, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan. zahra.hasan@aku.edu.
Source: Scientific reports [Sci Rep] 2026 Jan 21; Vol. 16 (1), pp. 4247. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-025-34370-z