The Population Neuroscience-Dementia Syndemics Framework to better understand global sex and gender-based risk in low- and middle-income countries.

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Title: The Population Neuroscience-Dementia Syndemics Framework to better understand global sex and gender-based risk in low- and middle-income countries.
Authors: Shaaban CE; Department of Health Promotion and Development, School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. Beth.Shaaban@pitt.edu.; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Beth.Shaaban@pitt.edu.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA. Beth.Shaaban@pitt.edu., Suryadevara V; Department of Radiology, Stanford University, Stanford, CA, USA., Hill AV; Department of Community Health Sciences, University of Illinois Chicago, Chicago, IL, USA., Milani SA; Department of Epidemiology, School of Public and Population Health, University of Texas Medical Branch, Galveston, TX, USA., Agarwal P; Rush Alzheimer's Disease Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA., Aggarwal NT; Department of Neurological Sciences, Rush Medical College, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University, Chicago, IL, USA., Akinyemi RO; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Centre for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Neurology, University College Hospital, Ibadan, Nigeria.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Alladi S; Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India., Brown MJ; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.; South Carolina SmartState Center for Healthcare Quality, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.; Rural and Minority Health Research Center, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.; Office for the Study on Aging, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.; Centre for Health Systems Research & Development, University of the Free State, Bloemfontein, South Africa., Caldwell JZK; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA., Caramelli P; Behavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., DuBose L; Department of Medicine, Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Ellajosyula R; Annasawmy Mudaliar General Hospital, Bangalore, India.; Manipal Hospitals, Bangalore, India., Esiaka DK; Center for Health Engagement and Transformation, University of Kentucky College of Medicine, Lexington, KY, USA., Gibson A; School of Social Work, Saint Louis University, St. Louis, MO, USA., Griffith P; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Harper J; Department of Technology and Applied Sciences, Universidad Comunera, Asunción, Paraguay., Karanja W; Brain and Mind Institute, Aga Khan University, Nairobi, Kenya.; Global Brain Health Institute, Trinity College, Dublin, Ireland., Li W; Department of Clinical and Diagnostic Sciences, University of Alabama at Birmingham, Birmingham, AL, USA., Llibre-Guerra JJ; Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Loi SM; Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.; Neuropsychiatry, Royal Melbourne Hospital, Melbourne, Victoria, Australia., Mielke MM; Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Molina-Henry DP; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Alzheimer's Therapeutic Research Institute, University of Southern California, Los Angeles, CA, USA., Ogunniyi A; Department of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria., Pudumjee S; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA., Stites SD; Department of Psychiatry and Division of Geriatric Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sundermann E; Department of Psychiatry, University of California, San Diego, San Diego, CA, USA., Turner AD; Department of Psychiatry & Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, FL, USA., Vila-Castelar C; Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Viswanathan J; Independent researcher, Bethesda, MD, USA., Trani JF; School of Public Health, Washington University in St. Louis, St. Louis, MO, USA.; National Conservatory of Arts and Crafts, Paris, France.; Department of Psychology, Faculty of Humanities, University of Johannesburg, Johannesburg, South Africa., Babulal GM; Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.; Department of Psychology, Faculty of Humanities, University of Johannesburg, Johannesburg, South Africa.; Institute of Public Health, Washington University, St. Louis, MO, USA.
Corporate Authors: Diversity and Disparities Professional Interest Area’s Low- and Middle-Income Countries Work Group of the International Society to Advance Alzheimer’s Research and Treatment (ISTAART), Diversity and Disparities Professional Interest Area’s Sex and Gender Special Interest Group of the International Society to Advance Alzheimer’s Research and Treatment (ISTAART)
Source: Nature aging [Nat Aging] 2026 Jan; Vol. 6 (1), pp. 38-55. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-8465
DOI:10.1038/s43587-025-01035-5