A dual role of hippocampal perineuronal nets in plasticity and protection is revealed by improvement and impairment of diet-induced memory dysfunction.

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Title: A dual role of hippocampal perineuronal nets in plasticity and protection is revealed by improvement and impairment of diet-induced memory dysfunction.
Authors: Reichelt AC; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada.; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia., Hashad AM; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Ghosh-Swaby OR; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada. oghoshsw@uwo.ca.; Western Institute for Neuroscience, Western University, London, ON, Canada. oghoshsw@uwo.ca., Skirzewski M; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada.; Western Institute for Neuroscience, Western University, London, ON, Canada., Scott GA; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada., Machado M; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada., Kramar CP; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada.; Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, QC, Canada., Princz-Lebel O; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada., Inoue W; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada.; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Bussey TJ; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada.; Western Institute for Neuroscience, Western University, London, ON, Canada., Saksida LM; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada.; Western Institute for Neuroscience, Western University, London, ON, Canada.
Source: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2026 Jun; Vol. 51 (7), pp. 1245-1257. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1740-634X
DOI:10.1038/s41386-026-02343-z