Retinal determination network reactivation drives chemoresistance and blocks myeloid differentiation in acute myeloid leukemia.

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Title: Retinal determination network reactivation drives chemoresistance and blocks myeloid differentiation in acute myeloid leukemia.
Authors: Clayfield L; Cancer Research UK, Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Paterson Building, Wilmslow Rd, Manchester M20 4BX, UK., Malik D; Cancer Research UK, Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Paterson Building, Wilmslow Rd, Manchester M20 4BX, UK., Whittle J; Cancer Research UK, Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Paterson Building, Wilmslow Rd, Manchester M20 4BX, UK., Xu J; Cancer Research UK, Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Paterson Building, Wilmslow Rd, Manchester M20 4BX, UK., Mevel R; Cancer Research UK, Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Paterson Building, Wilmslow Rd, Manchester M20 4BX, UK., Fadlullah MZH; Cancer Research UK, Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Paterson Building, Wilmslow Rd, Manchester M20 4BX, UK., Patel R; Cancer Research UK, Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Paterson Building, Wilmslow Rd, Manchester M20 4BX, UK., Szpakowska M; Luxembourg Institute of Health, Department of Infection and Immunity, Immuno-Pharmacology and Interactomics, 4354 Esch-sur-Alzette, Luxembourg., Maqbool MA; Cancer Research UK, Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Paterson Building, Wilmslow Rd, Manchester M20 4BX, UK., Jones M; Cancer Research UK, Leukaemia Biology Group, Cancer Research UK Manchester Institute, Paterson Building, Wilmslow Rd, Manchester M20 4BX, UK., Lie-A-Ling M; Cancer Research UK, Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Paterson Building, Wilmslow Rd, Manchester M20 4BX, UK., Chevigne A; Luxembourg Institute of Health, Department of Infection and Immunity, Immuno-Pharmacology and Interactomics, 4354 Esch-sur-Alzette, Luxembourg., Paggetti J; Luxembourg Institute of Health, Department of Oncology, Tumor Stroma Interactions, 1526 Luxembourg, Luxembourg., Moussay E; Luxembourg Institute of Health, Department of Oncology, Tumor Stroma Interactions, 1526 Luxembourg, Luxembourg., Baker SM; Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Iqbal M; Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Maire P; Université de Paris, Institut Cochin, INSERM, CNRS, 75014 Paris, France., Somervaille TCP; Cancer Research UK, Leukaemia Biology Group, Cancer Research UK Manchester Institute, Paterson Building, Wilmslow Rd, Manchester M20 4BX, UK., Ford HL; University of Colorado School of Medicine, University of Colorado Cancer Center, Aurora CO 80045, USA., Kouskoff V; Division of Developmental Biology & Medicine, The University of Manchester, Manchester M13 9PT, UK. Electronic address: valerie.kouskoff@manchester.ac.uk., Largeot A; Luxembourg Institute of Health, Department of Oncology, Tumor Stroma Interactions, 1526 Luxembourg, Luxembourg. Electronic address: anne.largeot@lih.lu., Lacaud G; Cancer Research UK, Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Paterson Building, Wilmslow Rd, Manchester M20 4BX, UK. Electronic address: georges.lacaud@cruk.manchester.ac.uk.
Source: Cell reports [Cell Rep] 2026 Feb 24; Vol. 45 (2), pp. 116875. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2025.116875