Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection.
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| Title: | Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection. |
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| Authors: | Watanabe Y; Department of Virology, The JIKEI University School of Medicine, Tokyo, Japan.; Department of Infectious Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ibrahim MS; Department of Virology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Arai Y; Department of Infectious Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kuroda D; Department of Biosciences, College of Humanities and Sciences, Nihon University, Tokyo, Japan., Elgendy EM; Department of Virology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Nakakita SI; Division of Functional Glycomics, Kagawa University, Kagawa, Japan., Takeda Y; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.; Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan., Nghia Bui V; Virology Department, National Institute of Veterinary Research, Hanoi, Vietnam., Ono T; Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, The University of Osaka, Osaka, Japan., Ushiba S; Murata Manufacturing Co., Ltd, Kyoto, Japan., Daidoji T; Department of Infectious Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.; Department of Pathobiology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan., Sriwilaijaroen N; Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan., Ogawa H; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan., Matsumoto K; SANKEN, The University of Osaka, Osaka, Japan., Suzuki Y; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan., Nakaya T; Department of Infectious Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. |
| Source: | PLoS pathogens [PLoS Pathog] 2026 Jan 23; Vol. 22 (1), pp. e1013863. Date of Electronic Publication: 2026 Jan 23 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1553-7374 |
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| DOI: | 10.1371/journal.ppat.1013863 |
