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Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection.

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Title: Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection.
Authors: Watanabe Y; Department of Virology, The JIKEI University School of Medicine, Tokyo, Japan.; Department of Infectious Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ibrahim MS; Department of Virology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Arai Y; Department of Infectious Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kuroda D; Department of Biosciences, College of Humanities and Sciences, Nihon University, Tokyo, Japan., Elgendy EM; Department of Virology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Nakakita SI; Division of Functional Glycomics, Kagawa University, Kagawa, Japan., Takeda Y; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.; Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan., Nghia Bui V; Virology Department, National Institute of Veterinary Research, Hanoi, Vietnam., Ono T; Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, The University of Osaka, Osaka, Japan., Ushiba S; Murata Manufacturing Co., Ltd, Kyoto, Japan., Daidoji T; Department of Infectious Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.; Department of Pathobiology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan., Sriwilaijaroen N; Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan., Ogawa H; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan., Matsumoto K; SANKEN, The University of Osaka, Osaka, Japan., Suzuki Y; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan., Nakaya T; Department of Infectious Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Source: PLoS pathogens [PLoS Pathog] 2026 Jan 23; Vol. 22 (1), pp. e1013863. Date of Electronic Publication: 2026 Jan 23 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection.
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  Data: <searchLink fieldCode="AU" term="%22Watanabe+Y%22">Watanabe Y</searchLink>; Department of Virology, The JIKEI University School of Medicine, Tokyo, Japan.; Department of Infectious Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ibrahim+MS%22">Ibrahim MS</searchLink>; Department of Virology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.<br /><searchLink fieldCode="AU" term="%22Arai+Y%22">Arai Y</searchLink>; Department of Infectious Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kuroda+D%22">Kuroda D</searchLink>; Department of Biosciences, College of Humanities and Sciences, Nihon University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Elgendy+EM%22">Elgendy EM</searchLink>; Department of Virology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.<br /><searchLink fieldCode="AU" term="%22Nakakita+SI%22">Nakakita SI</searchLink>; Division of Functional Glycomics, Kagawa University, Kagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Takeda+Y%22">Takeda Y</searchLink>; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.; Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Nghia+Bui+V%22">Nghia Bui V</searchLink>; Virology Department, National Institute of Veterinary Research, Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Ono+T%22">Ono T</searchLink>; Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, The University of Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ushiba+S%22">Ushiba S</searchLink>; Murata Manufacturing Co., Ltd, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Daidoji+T%22">Daidoji T</searchLink>; Department of Infectious Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.; Department of Pathobiology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Sriwilaijaroen+N%22">Sriwilaijaroen N</searchLink>; Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Ogawa+H%22">Ogawa H</searchLink>; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Matsumoto+K%22">Matsumoto K</searchLink>; SANKEN, The University of Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+Y%22">Suzuki Y</searchLink>; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Nakaya+T%22">Nakaya T</searchLink>; Department of Infectious Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101238921%22">PLoS pathogens</searchLink> [PLoS Pathog] 2026 Jan 23; Vol. 22 (1), pp. e1013863. <i>Date of Electronic Publication: </i>2026 Jan 23 (<i>Print Publication: </i>2026).
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