A paracrine-to-autocrine shunt of GREM1 fuels colorectal cancer metastasis via ACVR1C.

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Title: A paracrine-to-autocrine shunt of GREM1 fuels colorectal cancer metastasis via ACVR1C.
Authors: Zhou H; Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Jin Q; Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.; Inner Mongolia Honder College of Arts and Sciences, Hohhot, China.; Digestive Diseases Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Fu Z; Department of Geriatrics, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Yang Y; Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Gao Y; Department of Otolaryngology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Wang N; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China., Zhao B; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China., Gui L; Institute of Bio-Architecture and Bio-Interactions, Shenzhen Medical Academy of Research and Translation, Shenzhen, China., Li J; Clinical Big Data Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Zhu Z; Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China., Zhang Y; Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., He Y; Digestive Diseases Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Zhang Y; The Francis Crick Institute, London, UK., Luo S; Peninsula Medical School, Faculty of Health, University of Plymouth, Plymouth, UK., Fu L; Guangdong Key Laboratory for Genome Stability & Disease Prevention, Department of Pharmacology and Shenzhen International Cancer Center, Shenzhen University Medical School, Shenzhen University, Shenzhen, China., Wu X; The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China., Wang G; GI Cancer Research Institute, Tongji Hospital, and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China., Xu Z; Future Medical Center, Shenzhen University of Advanced Technology, Shenzhen, China., Li H; Wolfson Institute for Biomedical Research, Division of Medicine, Faculty of Medical Sciences, University College London, London, UK., Zhang J; Department of Hepato-Biliary Surgery, Inner Mongolia Key Laboratory of Allergic Diseases, Hohhot First Hospital, Hohhot, China., Shen X; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, China. snowshen@mac.com., Wang T; Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. wangtao@sysush.com., Jiang Y; Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. jiangyouheng1@sysush.com.; Digestive Diseases Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. jiangyouheng1@sysush.com.; Shenzhen Clinical Research Center for Gastroenterology (Gastrointestinal Surgery), Shenzhen, China. jiangyouheng1@sysush.com., Li N; Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. linn29@mail.sysu.edu.cn.; Inner Mongolia Honder College of Arts and Sciences, Hohhot, China. linn29@mail.sysu.edu.cn.; Future Medical Center, Shenzhen University of Advanced Technology, Shenzhen, China. linn29@mail.sysu.edu.cn.; Department of Hepato-Biliary Surgery, Inner Mongolia Key Laboratory of Allergic Diseases, Hohhot First Hospital, Hohhot, China. linn29@mail.sysu.edu.cn.; Shenzhen Clinical Research Center for Gastroenterology (Gastrointestinal Surgery), Shenzhen, China. linn29@mail.sysu.edu.cn.
Source: Molecular cancer [Mol Cancer] 2026 Jan 24. Date of Electronic Publication: 2026 Jan 24.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4598
DOI:10.1186/s12943-025-02554-w