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AFP-specific T cell receptors with fine-tuning affinity induce durable tumor remission in mice and acquire pan-HLA-A∗02 recognition.

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Title: AFP-specific T cell receptors with fine-tuning affinity induce durable tumor remission in mice and acquire pan-HLA-A∗02 recognition.
Authors: Huang CS; Department of Pancreato-Biliary Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China., Du J; HRYZ Biotech Co., Guangzhou 510525, China., Li J; HRYZ Biotech Co., Guangzhou 510525, China., Guo YH; Department of Pancreato-Biliary Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China., Yan Q; HRYZ Biotech Co., Guangzhou 510525, China., Wu S; HRYZ Biotech Co., Guangzhou 510525, China., Chen X; HRYZ Biotech Co., Guangzhou 510525, China., Leong TF; HRYZ Biotech Co., Guangzhou 510525, China., Chen SY; Key Laboratory of Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou 510080, China., Zheng AD; Department of Pancreato-Biliary Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China., Ou S; HRYZ Biotech Co., Guangzhou 510525, China., Ma M; HRYZ Biotech Co., Guangzhou 510525, China., Yang C; HRYZ Biotech Co., Guangzhou 510525, China., Zhang L; HRYZ Biotech Co., Guangzhou 510525, China., Zhou X; HRYZ Biotech Co., Guangzhou 510525, China., Chu J; HRYZ Biotech Co., Guangzhou 510525, China. Electronic address: chujunjun@gmail.com., Han Y; HRYZ Biotech Co., Guangzhou 510525, China. Electronic address: hanyy@thyx.com.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 May 06; Vol. 34 (5), pp. 2666-2677. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2026.01.026