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CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL.

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Title: CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL.
Authors: Mikami T; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan., Kato I; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. Electronic address: itarkt@kuhp.kyoto-u.ac.jp., Llamas-Covarrubias MA; Laboratory of Human Single Cell Immunology, Immunology Frontier Research Center (IFReC), The University of Osaka, Suita 565-0871, Osaka, Japan., Hiramatsu H; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan; Department of Pediatrics, Kindai University Faculty of Medicine, Sakai 590-0197, Osaka, Japan., Uchihara Y; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan., Mitsuyoshi T; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8397, Japan., Kitawaki T; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8397, Japan., Saida S; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan., Umeda K; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan., Ogawa S; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto 606-8501, Japan., Takaori-Kondo A; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8397, Japan., Wing JB; Laboratory of Human Single Cell Immunology, Immunology Frontier Research Center (IFReC), The University of Osaka, Suita 565-0871, Osaka, Japan; Human Single Cell Immunology Team, Center for Infectious Disease Education and Research (CiDER), The University of Osaka, Suita 565-0871, Osaka, Japan; Center for Advanced Modalities and DDS (CAMaD), The University of Osaka, Suita 565-0871, Osaka, Japan., Takita J; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. Electronic address: jtakita@kuhp.kyoto-u.ac.jp.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Feb 17; Vol. 7 (2), pp. 102576. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-3791
DOI:10.1016/j.xcrm.2025.102576