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CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL.

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Title: CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL.
Authors: Mikami T; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan., Kato I; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. Electronic address: itarkt@kuhp.kyoto-u.ac.jp., Llamas-Covarrubias MA; Laboratory of Human Single Cell Immunology, Immunology Frontier Research Center (IFReC), The University of Osaka, Suita 565-0871, Osaka, Japan., Hiramatsu H; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan; Department of Pediatrics, Kindai University Faculty of Medicine, Sakai 590-0197, Osaka, Japan., Uchihara Y; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan., Mitsuyoshi T; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8397, Japan., Kitawaki T; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8397, Japan., Saida S; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan., Umeda K; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan., Ogawa S; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto 606-8501, Japan., Takaori-Kondo A; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8397, Japan., Wing JB; Laboratory of Human Single Cell Immunology, Immunology Frontier Research Center (IFReC), The University of Osaka, Suita 565-0871, Osaka, Japan; Human Single Cell Immunology Team, Center for Infectious Disease Education and Research (CiDER), The University of Osaka, Suita 565-0871, Osaka, Japan; Center for Advanced Modalities and DDS (CAMaD), The University of Osaka, Suita 565-0871, Osaka, Japan., Takita J; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. Electronic address: jtakita@kuhp.kyoto-u.ac.jp.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Feb 17; Vol. 7 (2), pp. 102576. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: CAR-T cells with the CD38<superscript>-</superscript>CD73<superscript>-</superscript>Tim-3<superscript>-</superscript>HLA-DR<superscript>+</superscript> phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL.
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  Data: <searchLink fieldCode="AU" term="%22Mikami+T%22">Mikami T</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+I%22">Kato I</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. Electronic address: itarkt@kuhp.kyoto-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Llamas-Covarrubias+MA%22">Llamas-Covarrubias MA</searchLink>; Laboratory of Human Single Cell Immunology, Immunology Frontier Research Center (IFReC), The University of Osaka, Suita 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Hiramatsu+H%22">Hiramatsu H</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan; Department of Pediatrics, Kindai University Faculty of Medicine, Sakai 590-0197, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Uchihara+Y%22">Uchihara Y</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.<br /><searchLink fieldCode="AU" term="%22Mitsuyoshi+T%22">Mitsuyoshi T</searchLink>; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8397, Japan.<br /><searchLink fieldCode="AU" term="%22Kitawaki+T%22">Kitawaki T</searchLink>; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8397, Japan.<br /><searchLink fieldCode="AU" term="%22Saida+S%22">Saida S</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.<br /><searchLink fieldCode="AU" term="%22Umeda+K%22">Umeda K</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.<br /><searchLink fieldCode="AU" term="%22Ogawa+S%22">Ogawa S</searchLink>; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto 606-8501, Japan.<br /><searchLink fieldCode="AU" term="%22Takaori-Kondo+A%22">Takaori-Kondo A</searchLink>; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8397, Japan.<br /><searchLink fieldCode="AU" term="%22Wing+JB%22">Wing JB</searchLink>; Laboratory of Human Single Cell Immunology, Immunology Frontier Research Center (IFReC), The University of Osaka, Suita 565-0871, Osaka, Japan; Human Single Cell Immunology Team, Center for Infectious Disease Education and Research (CiDER), The University of Osaka, Suita 565-0871, Osaka, Japan; Center for Advanced Modalities and DDS (CAMaD), The University of Osaka, Suita 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Takita+J%22">Takita J</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. Electronic address: jtakita@kuhp.kyoto-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101766894%22">Cell reports. Medicine</searchLink> [Cell Rep Med] 2026 Feb 17; Vol. 7 (2), pp. 102576. <i>Date of Electronic Publication: </i>2026 Jan 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101766894 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2666-3791 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226663791%22">26663791 </searchLink><i>NLM ISO Abbreviation: </i>Cell Rep Med <i>Subsets: </i>MEDLINE
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      – TitleFull: CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL.
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              Text: 2026 Feb 17
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