Sustained HIF activation in adult cardiomyocytes show transient beneficial effect in murine HFpEF model.
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| Title: | Sustained HIF activation in adult cardiomyocytes show transient beneficial effect in murine HFpEF model. |
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| Authors: | Sawaki D; Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.; Division of Cardiology and Metabolism, Centre for Molecular Medicine, 3311-1 Yakushiji, Shimotsuke, Jichi Medical University, Tochigi, 329-0498, Japan., Isagawa T; Division of Cardiology and Metabolism, Centre for Molecular Medicine, 3311-1 Yakushiji, Shimotsuke, Jichi Medical University, Tochigi, 329-0498, Japan.; Data Science Centre, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan., Sato S; Division of Cardiology and Metabolism, Centre for Molecular Medicine, 3311-1 Yakushiji, Shimotsuke, Jichi Medical University, Tochigi, 329-0498, Japan., Sato T; Division of Cardiology and Metabolism, Centre for Molecular Medicine, 3311-1 Yakushiji, Shimotsuke, Jichi Medical University, Tochigi, 329-0498, Japan.; Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan., Semba H; Division of Cardiology and Metabolism, Centre for Molecular Medicine, 3311-1 Yakushiji, Shimotsuke, Jichi Medical University, Tochigi, 329-0498, Japan., Sugimoto H; Division of Cardiology and Metabolism, Centre for Molecular Medicine, 3311-1 Yakushiji, Shimotsuke, Jichi Medical University, Tochigi, 329-0498, Japan., Ono K; Division of Cardiology and Metabolism, Centre for Molecular Medicine, 3311-1 Yakushiji, Shimotsuke, Jichi Medical University, Tochigi, 329-0498, Japan.; Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan., Chuluun-Erdene A; Division of Cardiology and Metabolism, Centre for Molecular Medicine, 3311-1 Yakushiji, Shimotsuke, Jichi Medical University, Tochigi, 329-0498, Japan., Pham TT; Division of Cardiology and Metabolism, Centre for Molecular Medicine, 3311-1 Yakushiji, Shimotsuke, Jichi Medical University, Tochigi, 329-0498, Japan., Tanaka R; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan., Kawakami T; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan., Ito M; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan., Minatsuki S; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan., Higashikuni Y; Division of Cardiovascular and Genetic Research, Centre for Molecular Medicine, Jichi Medical University, Tochigi, 329-0498, Japan., Asagiri M; Department of Pharmacology, Graduate School of Medicine and RICeD, Yamaguchi University, 1-1-1 Minai-Kogushi, Ube, Yamaguchi, 755-8505, Japan., Manabe I; Department of Systems Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan., Kohro T; Data Science Centre, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan., Kuchimaru T; Division of Cardiology and Metabolism, Centre for Molecular Medicine, 3311-1 Yakushiji, Shimotsuke, Jichi Medical University, Tochigi, 329-0498, Japan., Imai Y; Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan., Takeda N; Division of Cardiology and Metabolism, Centre for Molecular Medicine, 3311-1 Yakushiji, Shimotsuke, Jichi Medical University, Tochigi, 329-0498, Japan.; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. |
| Source: | European heart journal open [Eur Heart J Open] 2026 Jan 22; Vol. 6 (1), pp. oeaf178. Date of Electronic Publication: 2026 Jan 22 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Published by Oxford University Press on behalf of the European Society of Cardiology Country of Publication: England NLM ID: 9918282081406676 Publication Model: eCollection Cited Medium: Internet ISSN: 2752-4191 (Electronic) Linking ISSN: 27524191 NLM ISO Abbreviation: Eur Heart J Open Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2752-4191 |
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| DOI: | 10.1093/ehjopen/oeaf178 |
