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CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting.

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Title: CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting.
Authors: Itoh-Nakadai A; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan.; Department of Hygiene and Public Health, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan., Liang M; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan.; Laboratory for Applied Computational Genomics, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan.; Department of Comprehensive Pathology, Institute of Science Tokyo, Tokyo, Japan., Shindo M; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Bibi C; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Tomizawa-Murasawa M; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Fujiki S; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Kaneko A; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Kanamaru E; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Hashimoto M; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Kajita H; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Ando Y; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Kojima M; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Moody J; Laboratory for Genome Information Analysis, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Iwasaki M; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Takagi S; Department of Hematology, Toranomon Hospital, Tokyo, Japan., Nakagawa R; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Agrawal S; Laboratory for Applied Computational Genomics, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Amitani-Iijima H; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Sato K; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Sorimachi Y; Department of Stem Cell Biology, National Institute of Global Health and Medicine, Japan Institute for Health Security (JIHS), Tokyo, Japan., Suzuki N; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Fukami T; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., Hanada K; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Morita S; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Katsura K; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Matsumoto T; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Kobayashi M; Department of Hygiene and Public Health, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan., Kato M; Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan., Negishi Y; Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.; Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan., Shirouzu M; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Najima Y; Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan., Takubo K; Department of Stem Cell Biology, National Institute of Global Health and Medicine, Japan Institute for Health Security (JIHS), Tokyo, Japan.; Department of Cell Fate Biology and Stem Cell Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan., Hon CC; Laboratory for Genome Information Analysis, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Uchida N; Department of Hematology, Toranomon Hospital, Tokyo, Japan., Taniguchi S; Department of Hematology, Toranomon Hospital, Tokyo, Japan.; Hamanomachi Hospital, Fukuoka, Japan., Momozawa Y; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Carninci P; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan.; Functional Genomics, Genomics Research Center, Human Technopole, Milan, Italy., Shultz LD; The Jackson Laboratory, Bar Harbor, ME, USA., Saito Y; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan., de Hoon M; Laboratory for Applied Computational Genomics, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan., Shin JW; Laboratory for Advanced Genomics Circuit, RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan.; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Singapore, Republic of Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Dr, Singapore, Republic of Singapore., Ishikawa F; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan. fumihiko.ishikawa@riken.jp.; Department of Comprehensive Pathology, Institute of Science Tokyo, Tokyo, Japan. fumihiko.ishikawa@riken.jp.
Source: Nature communications [Nat Commun] 2026 Jan 26; Vol. 17 (1), pp. 101. Date of Electronic Publication: 2026 Jan 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-67745-x