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Scalable and multiplexed recorders of gene regulation dynamics across weeks.

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Title: Scalable and multiplexed recorders of gene regulation dynamics across weeks.
Authors: Zheng L; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA., Shi D; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA., Yan Y; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA., Zhou B; Department of Computer Science and Technology, University of Cambridge, Cambridge, UK., Lim J; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA., Hou Y; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA., An B; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Adhinarta JK; Department of Computer Science, Boston College, Boston, MA, USA., Lin M; Department of Computer Science, Boston College, Boston, MA, USA., Ko B; Nash Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Joesten WC; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA., Gautam M; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA., Huez EDM; Kresge Hearing Research Institute and Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA., Kim EC; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Klyder EG; Department of Chemistry, University of Michigan, Ann Arbor, MI, USA., Chang B; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA., Pitchiaya S; Department of Urology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Roberts MT; Kresge Hearing Research Institute and Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA., Cai DJ; Nash Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Boyden ES; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Yang Tan Collective and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Wei D; Department of Computer Science, Boston College, Boston, MA, USA., Liò P; Department of Computer Science and Technology, University of Cambridge, Cambridge, UK., Linghu C; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA. linghu@umich.edu.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA. linghu@umich.edu.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. linghu@umich.edu.
Source: Nature [Nature] 2026 Apr; Vol. 652 (8111), pp. 1038-1048. Date of Electronic Publication: 2026 Jan 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Scalable and multiplexed recorders of gene regulation dynamics across weeks.
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  Data: <searchLink fieldCode="AU" term="%22Zheng+L%22">Zheng L</searchLink>; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Shi+D%22">Shi D</searchLink>; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Yan+Y%22">Yan Y</searchLink>; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+B%22">Zhou B</searchLink>; Department of Computer Science and Technology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lim+J%22">Lim J</searchLink>; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Hou+Y%22">Hou Y</searchLink>; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22An+B%22">An B</searchLink>; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Adhinarta+JK%22">Adhinarta JK</searchLink>; Department of Computer Science, Boston College, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+M%22">Lin M</searchLink>; Department of Computer Science, Boston College, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ko+B%22">Ko B</searchLink>; Nash Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Joesten+WC%22">Joesten WC</searchLink>; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gautam+M%22">Gautam M</searchLink>; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Huez+EDM%22">Huez EDM</searchLink>; Kresge Hearing Research Institute and Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Kim+EC%22">Kim EC</searchLink>; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Klyder+EG%22">Klyder EG</searchLink>; Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Chang+B%22">Chang B</searchLink>; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Pitchiaya+S%22">Pitchiaya S</searchLink>; Department of Urology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+MT%22">Roberts MT</searchLink>; Kresge Hearing Research Institute and Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Cai+DJ%22">Cai DJ</searchLink>; Nash Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Boyden+ES%22">Boyden ES</searchLink>; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Yang Tan Collective and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wei+D%22">Wei D</searchLink>; Department of Computer Science, Boston College, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liò+P%22">Liò P</searchLink>; Department of Computer Science and Technology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Linghu+C%22">Linghu C</searchLink>; Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA. linghu@umich.edu.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA. linghu@umich.edu.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. linghu@umich.edu.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Apr; Vol. 652 (8111), pp. 1038-1048. <i>Date of Electronic Publication: </i>2026 Jan 26.
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