Lysophosphatidic acid-induced upregulation of exosomal miR-221-3p from corneal stromal cells promotes corneal endothelial healing.

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Title: Lysophosphatidic acid-induced upregulation of exosomal miR-221-3p from corneal stromal cells promotes corneal endothelial healing.
Authors: Chen HC; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Department of Medicine, College of Medicine Chang Gung University, Taoyuan, Taiwan. Electronic address: mr3756@cgmh.org.tw., Hsueh YJ; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City, Taiwan., Meir YJ; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Department of Biomedical Sciences, College of Medicine Chang Gung University, Taoyuan, Taiwan., Lai JY; Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan; Department of Materials Engineering, Ming Chi University of Technology, New Taipei City, Taiwan., Huang CC; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan., Lu TT; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan., Cheng CM; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan., Lin SS; Department of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Hyperbaric Oxygen Medical Research Laboratory, Bone and Joint Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Ma DH; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Department of Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Wu WC; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Department of Medicine, College of Medicine Chang Gung University, Taoyuan, Taiwan.
Source: Biomaterials advances [Biomater Adv] 2026 May; Vol. 182, pp. 214719. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918383886206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-9508 (Electronic) Linking ISSN: 27729508 NLM ISO Abbreviation: Biomater Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2772-9508
DOI:10.1016/j.bioadv.2026.214719