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Efficacy and safety of opioid-receptor antagonists for opioid-induced constipation: a systematic review and meta-analysis.

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Title: Efficacy and safety of opioid-receptor antagonists for opioid-induced constipation: a systematic review and meta-analysis.
Authors: Li Y; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Tu Y; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Zhou Z; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Liao D; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., He Z; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Li Y; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Li B; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Liu Z; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Zhou Z; Department of Rehabilitation, Mianyang Hospital of Traditional Chinese Medicine, Mianyang, China., Ai S; Department of Rehabilitation, Mianyang Hospital of Traditional Chinese Medicine, Mianyang, China.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Jan 12; Vol. 16, pp. 1749875. Date of Electronic Publication: 2026 Jan 12 (Print Publication: 2025).
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:1663-9812
DOI:10.3389/fphar.2025.1749875