Neoadjuvant ipilimumab plus nivolumab in melanoma: 5-year survival and biomarker analysis from the phase 2 PRADO-trial.

Saved in:
Bibliographic Details
Title: Neoadjuvant ipilimumab plus nivolumab in melanoma: 5-year survival and biomarker analysis from the phase 2 PRADO-trial.
Authors: Hoeijmakers LL; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Dimitriadis P; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Wijnen SCMA; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Reijers ILM; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Lopez-Yurda M; Department of Biometrics, Netherlands Cancer Institute, Amsterdam, The Netherlands., Menzies AM; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Department of Medical Oncology, Royal North Shore and Mater Hospitals, Sydney, New South Wales, Australia., Broeks A; Core Facility Molecular Pathology & Biobanking Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital (NKI-AVL), Amsterdam, The Netherlands., Cornelissen S; Core Facility Molecular Pathology & Biobanking Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital (NKI-AVL), Amsterdam, The Netherlands., Torres Acosta A; Department of Biometrics, Netherlands Cancer Institute, Amsterdam, The Netherlands., van der Wal A; Department of Biometrics, Netherlands Cancer Institute, Amsterdam, The Netherlands., Saw RPM; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia., Versluis JM; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., van Houdt WJ; Department of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Wouters MW; Department of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands., Romano J; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Rozeman EA; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Grijpink-Ongering LG; Department of Biometrics, Netherlands Cancer Institute, Amsterdam, The Netherlands., Kapiteijn E; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands., van der Veldt AAM; Departments of Medical Oncology and Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Suijkerbuijk KPM; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Eriksson H; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.; Unit of Head, Neck, Lung, and Skin Cancer/Skin Cancer Center, Theme Cancer, Karolinska University Hospital, Stockholm, Sweden., Hospers GAP; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van der Hage JA; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Grünhagen DJ; Department of Surgical Oncology, Erasmus Medical Center, Rotterdam, The Netherlands., Witkamp AJ; Department of Surgical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Lijnsvelt JM; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Klop WMC; Department of Head and Neck Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands., Zuur CL; Department of Head and Neck Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Otorhinolaryngology Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands., Bruining A; Department of Radiology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Al-Mamgani A; Department of Radiotherapy, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Radiation Oncology, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Amsterdam, The Netherlands., Pennington TE; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia., Shannon KF; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia., Ch'ng S; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Colebatch AJ; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Department of Breast and Melanoma Surgery, Royal North Shore and Mater Hospitals, Sydney, New South Wales, Australia., Gonzalez M; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia., Spillane AJ; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital and NSW Health Pathology, Sydney, New South Wales, Australia., Haanen JBAG; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.; Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Rawson RV; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital and NSW Health Pathology, Sydney, New South Wales, Australia., Scolyer RA; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital and NSW Health Pathology, Sydney, New South Wales, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia., van de Wiel BA; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands., van Akkooi ACJ; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Department of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Long GV; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Department of Medical Oncology, Royal North Shore and Mater Hospitals, Sydney, New South Wales, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia., Blank CU; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. c.blank@nki.nl.; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands. c.blank@nki.nl.; Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands. c.blank@nki.nl.; Department of Hematology and Medical Oncology, University Clinic Regensburg, Regensburg, Germany. c.blank@nki.nl.; Division of Sarcoma and Melanoma, European Institute of Oncology, Milano, Italy. c.blank@nki.nl.
Source: Nature medicine [Nat Med] 2026 Mar; Vol. 32 (3), pp. 952-963. Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article; Clinical Trial, Phase II
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/s41591-025-04158-9