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Loss of MicroRNA-29b promotes DNMT3b-mediated STING downregulation to attenuate radiotherapy-induced antitumor immunity in KRAS-mutated colorectal cancer.

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Title: Loss of MicroRNA-29b promotes DNMT3b-mediated STING downregulation to attenuate radiotherapy-induced antitumor immunity in KRAS-mutated colorectal cancer.
Authors: Chang HY; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan., Chen JY; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Center of Proton therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan., Ke TW; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.; School of Chinese Medicine and Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan., Jiang YW; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Center of Proton therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan., Hong WZ; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Center of Proton therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan., Tsai YY; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan., Chiang SF; Lab of Precision Medicine, Feng-Yuan Hospital, Ministry of Health and Welfare, Taichung, Taiwan., Lin YS; Department of Chest Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan., Huang CH; Center of Proton therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan., Chen TH; Department of Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan., Chao KSC; Center of Proton therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan., Huang KC; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.; Office of Research and Development, Asia University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.
Source: NPJ precision oncology [NPJ Precis Oncol] 2026 Jan 28; Vol. 10 (1). Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Loss of MicroRNA-29b promotes DNMT3b-mediated STING downregulation to attenuate radiotherapy-induced antitumor immunity in KRAS-mutated colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Chang+HY%22">Chang HY</searchLink>; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+JY%22">Chen JY</searchLink>; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Center of Proton therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ke+TW%22">Ke TW</searchLink>; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.; School of Chinese Medicine and Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jiang+YW%22">Jiang YW</searchLink>; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Center of Proton therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hong+WZ%22">Hong WZ</searchLink>; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Center of Proton therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+YY%22">Tsai YY</searchLink>; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiang+SF%22">Chiang SF</searchLink>; Lab of Precision Medicine, Feng-Yuan Hospital, Ministry of Health and Welfare, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YS%22">Lin YS</searchLink>; Department of Chest Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CH%22">Huang CH</searchLink>; Center of Proton therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+TH%22">Chen TH</searchLink>; Department of Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chao+KSC%22">Chao KSC</searchLink>; Center of Proton therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+KC%22">Huang KC</searchLink>; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.; Office of Research and Development, Asia University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101708166%22">NPJ precision oncology</searchLink> [NPJ Precis Oncol] 2026 Jan 28; Vol. 10 (1). <i>Date of Electronic Publication: </i>2026 Jan 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101708166 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2397-768X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222397768X%22">2397768X </searchLink><i>NLM ISO Abbreviation: </i>NPJ Precis Oncol <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1038/s41698-026-01290-8
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              Text: 2026 Jan 28
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