The LMO2-LDB1-TAL1 complex regulates transcription networks in acute myeloid leukemia.

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Title: The LMO2-LDB1-TAL1 complex regulates transcription networks in acute myeloid leukemia.
Authors: Dunham N; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA., Wang Z; Department of Genome Sciences, University of Virginia, Charlottesville, VA., Neelamraju Y; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA., Guo Y; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL., Paudel BB; Division of Hematology and Medical Oncology, Department of Medicine, University of Virginia, Charlottesville, VA.; University of Virginia Comprehensive Cancer Center, Charlottesville, VA., Meydan C; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY., Gandara JA; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY., Abdelmalak FA; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA., Fan H; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA., Hardwick J; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.; Indiana University Simon Comprehensive Cancer Center, Indianapolis, IN., Layer JH; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.; Indiana University Simon Comprehensive Cancer Center, Indianapolis, IN., Lee T; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY., Maier B; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.; Indiana University Simon Comprehensive Cancer Center, Indianapolis, IN., McDonald WH; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN.; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN., Patnaik I; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA., Prajapati S; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA., Rapaport F; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY., Sheridan C; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY., Sheynkman G; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA.; University of Virginia Comprehensive Cancer Center, Charlottesville, VA.; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA., Zumbo P; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY., Becker MW; Department of Medicine, University of Rochester, Rochester, NY., Bullinger L; Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany.; Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, Berlin, Germany., Carroll MP; Division of Hematology and Oncology, University of Pennsylvania Perelman School of Medicine, Pennsylvania, PA., D'Andrea RJ; Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia., Dillon R; Department of Medical and Molecular Genetics, King's College London, London, United Kingdom., Levine RL; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY., Mason CE; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY.; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY.; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY., Melnick AM; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY., Neuberg DS; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA., Bekiranov S; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA., Zang C; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA.; Department of Genome Sciences, University of Virginia, Charlottesville, VA.; University of Virginia Comprehensive Cancer Center, Charlottesville, VA., Davé UP; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.; Indiana University Simon Comprehensive Cancer Center, Indianapolis, IN.; Division of Hematology, R.L. Roudebush Indianapolis VA Medical Center, Indianapolis, IN., Garrett-Bakelman FE; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA.; Division of Hematology and Medical Oncology, Department of Medicine, University of Virginia, Charlottesville, VA.; University of Virginia Comprehensive Cancer Center, Charlottesville, VA.; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY.
Source: Blood neoplasia [Blood Neoplasia] 2025 Nov 25; Vol. 3 (1), pp. 100186. Date of Electronic Publication: 2025 Nov 25 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918841988906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2950-3280 (Electronic) Linking ISSN: 29503280 NLM ISO Abbreviation: Blood Neoplasia Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2950-3280
DOI:10.1016/j.bneo.2025.100186