Combining sorafenib with spermine and sphingosine synergistically enhances anticancer efficacy by modulating metabolic pathways and gut microbiome in hepatocellular carcinoma.
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| Title: | Combining sorafenib with spermine and sphingosine synergistically enhances anticancer efficacy by modulating metabolic pathways and gut microbiome in hepatocellular carcinoma. |
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| Authors: | Jang HR; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea., Kim HJ; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea., Kim BY; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea., Jeong JH; School of Pharmacy, Institute of New Drug Development, Jeonbuk National University, Jeonju, Republic of Korea., Kim JK; School of Pharmacy, Institute of New Drug Development, Jeonbuk National University, Jeonju, Republic of Korea., Won JA; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.; Pharmacomicrobiomics Research Center, College of Pharmacy, Hanyang University, Ansan, Republic of Korea., Yoo HH; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.; Pharmacomicrobiomics Research Center, College of Pharmacy, Hanyang University, Ansan, Republic of Korea., Lee YG; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.; Pharmacomicrobiomics Research Center, College of Pharmacy, Hanyang University, Ansan, Republic of Korea., Yim H; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.; Pharmacomicrobiomics Research Center, College of Pharmacy, Hanyang University, Ansan, Republic of Korea. |
| Source: | International journal of biological sciences [Int J Biol Sci] 2026 Jan 01; Vol. 22 (3), pp. 1082-1102. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41608628 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Combining sorafenib with spermine and sphingosine synergistically enhances anticancer efficacy by modulating metabolic pathways and gut microbiome in hepatocellular carcinoma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Jang+HR%22">Jang HR</searchLink>; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+HJ%22">Kim HJ</searchLink>; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+BY%22">Kim BY</searchLink>; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeong+JH%22">Jeong JH</searchLink>; School of Pharmacy, Institute of New Drug Development, Jeonbuk National University, Jeonju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+JK%22">Kim JK</searchLink>; School of Pharmacy, Institute of New Drug Development, Jeonbuk National University, Jeonju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Won+JA%22">Won JA</searchLink>; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.; Pharmacomicrobiomics Research Center, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yoo+HH%22">Yoo HH</searchLink>; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.; Pharmacomicrobiomics Research Center, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+YG%22">Lee YG</searchLink>; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.; Pharmacomicrobiomics Research Center, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yim+H%22">Yim H</searchLink>; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Republic of Korea.; Pharmacomicrobiomics Research Center, College of Pharmacy, Hanyang University, Ansan, Republic of Korea. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101235568%22">International journal of biological sciences</searchLink> [Int J Biol Sci] 2026 Jan 01; Vol. 22 (3), pp. 1082-1102. <i>Date of Electronic Publication: </i>2026 Jan 01 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ivyspring+International%22">Ivyspring International </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>101235568 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1449-2288 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214492288%22">14492288 </searchLink><i>NLM ISO Abbreviation: </i>Int J Biol Sci <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41608628 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.7150/ijbs.118753 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1082 Titles: – TitleFull: Combining sorafenib with spermine and sphingosine synergistically enhances anticancer efficacy by modulating metabolic pathways and gut microbiome in hepatocellular carcinoma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jang HR – PersonEntity: Name: NameFull: Kim HJ – PersonEntity: Name: NameFull: Kim BY – PersonEntity: Name: NameFull: Jeong JH – PersonEntity: Name: NameFull: Kim JK – PersonEntity: Name: NameFull: Won JA – PersonEntity: Name: NameFull: Yoo HH – PersonEntity: Name: NameFull: Lee YG – PersonEntity: Name: NameFull: Yim H IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Jan 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1449-2288 Numbering: – Type: volume Value: 22 – Type: issue Value: 3 Titles: – TitleFull: International journal of biological sciences Type: main |
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