Elucidation of gene clusters underlying withanolide biosynthesis in ashwagandha through yeast metabolic engineering.

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Title: Elucidation of gene clusters underlying withanolide biosynthesis in ashwagandha through yeast metabolic engineering.
Authors: Reynolds EE; Institute for Plant-Human Interface, Northeastern University, Boston, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Department of Bioengineering, and Department of Chemical Engineering, Northeastern University, Boston, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Trauger M; Institute for Plant-Human Interface, Northeastern University, Boston, MA, USA.; Department of Chemistry and Chemical Biology, Department of Bioengineering, and Department of Chemical Engineering, Northeastern University, Boston, MA, USA., Li FS; Institute for Plant-Human Interface, Northeastern University, Boston, MA, USA.; Department of Chemistry and Chemical Biology, Department of Bioengineering, and Department of Chemical Engineering, Northeastern University, Boston, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Huang J; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Moss T; Institute for Plant-Human Interface, Northeastern University, Boston, MA, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Christ B; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Xu M; Institute for Plant-Human Interface, Northeastern University, Boston, MA, USA.; Department of Chemistry and Chemical Biology, Department of Bioengineering, and Department of Chemical Engineering, Northeastern University, Boston, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Knoch E; RIKEN Center for Sustainable Resource Science, Yokohama, Japan., Weng JK; Institute for Plant-Human Interface, Northeastern University, Boston, MA, USA. jingke.weng@northeastern.edu.; Department of Chemistry and Chemical Biology, Department of Bioengineering, and Department of Chemical Engineering, Northeastern University, Boston, MA, USA. jingke.weng@northeastern.edu.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA. jingke.weng@northeastern.edu.
Source: Nature plants [Nat Plants] 2026 Feb; Vol. 12 (2), pp. 432-446. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, a division of Macmillan Publishers Limited Country of Publication: England NLM ID: 101651677 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2055-0278 (Electronic) Linking ISSN: 20550278 NLM ISO Abbreviation: Nat Plants Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2055-0278
DOI:10.1038/s41477-026-02220-z