HP1β recruits RING1A to ubiquitinate histone H2A for BRCA1-mediated resection of double-stand breaks.

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Title: HP1β recruits RING1A to ubiquitinate histone H2A for BRCA1-mediated resection of double-stand breaks.
Authors: Charaka V; Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA.; Takeda Pharmaceutical, 300 Massachusetts Ave, Cambridge, MA 02139, USA., Pandita RK; Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA.; Center for Genomic and Precision Medicine, Institute of Biosciences and Technology, Texas A&M College of Medicine, Houston, TX 77030, USA., Tsai CL; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wang X; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Chakraborty S; Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA., Ramos KS; Center for Genomic and Precision Medicine, Institute of Biosciences and Technology, Texas A&M College of Medicine, Houston, TX 77030, USA., Nandi S; Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Leonard F; Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA., Singh V; Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Sarkar PS; Department of Neurobiology and Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA., Hunt CR; Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA., Tainer JA; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Das C; Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Pandita TK; Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA.; Center for Genomic and Precision Medicine, Institute of Biosciences and Technology, Texas A&M College of Medicine, Houston, TX 77030, USA.
Source: IScience [iScience] 2025 Dec 30; Vol. 29 (2), pp. 114582. Date of Electronic Publication: 2025 Dec 30 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-0042
DOI:10.1016/j.isci.2025.114582