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Oral Semaglutide and Heart Failure Outcomes in Persons With Type 2 Diabetes: A Secondary Analysis of the SOUL Randomized Clinical Trial.

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Title: Oral Semaglutide and Heart Failure Outcomes in Persons With Type 2 Diabetes: A Secondary Analysis of the SOUL Randomized Clinical Trial.
Authors: Pop-Busui R; Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health & Science University, Portland.; Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor., Rasmussen S; Novo Nordisk A/S, Søborg, Denmark., Deanfield JE; Institute of Cardiovascular Sciences, University College London, London, England, United Kingdom., Buse JB; University of North Carolina School of Medicine, Chapel Hill., Marx N; Clinic for Cardiology, Angiology, and Intensive Care Medicine, RWTH Aachen University, University Hospital Aachen, Aachen, Germany., Mulvagh SL; Division of Cardiology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Inzucchi SE; Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut., Mann JFE; KfH Kidney Center, Munich, Germany.; Friedrich Alexander University of Erlangen, Erlangen, Germany., Emerson SS; Department of Biostatistics, School of Public Health, University of Washington, Seattle., Poulter NR; Imperial Clinical Trials Unit, Faculty of Medicine, Imperial College London, London, England, United Kingdom., Engelmann MDM; Novo Nordisk A/S, Søborg, Denmark., Hovingh GK; Novo Nordisk A/S, Søborg, Denmark., Bayer Tanggaard K; Novo Nordisk A/S, Søborg, Denmark., Birkenfeld AL; Department of Diabetology, Endocrinology and Nephrology, University Hospital Tübingen, Tübingen, Germany.; Institute for Diabetes Research and Metabolic Diseases of Helmholtz Munich, Eberhard Karls University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany., Connelly KA; Keenan Research Centre for Biomedical Science, Departments of Medicine and Cardiology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Haluzik M; Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czechia., Cavender MA; University of North Carolina School of Medicine, Chapel Hill., Kellerer M; Department of Diabetology and Endocrinology, Clinic for Internal Medicine, Marienhospital Stuttgart, Stuttgart, Germany., Jhund PS; British Heart Foundation Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom., Gregersen S; Steno Diabetes Center Aarhus, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Nielsen OW; Novo Nordisk A/S, Søborg, Denmark., Lam CSP; National Heart Centre Singapore, Outram, Singapore.; Duke-National University of Singapore, Outram, Singapore., McGuire DK; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Parkland Health System, Dallas.
Corporate Authors: SOUL Study Group
Source: JAMA internal medicine [JAMA Intern Med] 2026 Apr 01; Vol. 186 (4), pp. 426-436.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589534 Publication Model: Print Cited Medium: Internet ISSN: 2168-6114 (Electronic) Linking ISSN: 21686106 NLM ISO Abbreviation: JAMA Intern Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Oral Semaglutide and Heart Failure Outcomes in Persons With Type 2 Diabetes: A Secondary Analysis of the SOUL Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Pop-Busui+R%22">Pop-Busui R</searchLink>; Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health & Science University, Portland.; Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor.<br /><searchLink fieldCode="AU" term="%22Rasmussen+S%22">Rasmussen S</searchLink>; Novo Nordisk A/S, Søborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Deanfield+JE%22">Deanfield JE</searchLink>; Institute of Cardiovascular Sciences, University College London, London, England, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Buse+JB%22">Buse JB</searchLink>; University of North Carolina School of Medicine, Chapel Hill.<br /><searchLink fieldCode="AU" term="%22Marx+N%22">Marx N</searchLink>; Clinic for Cardiology, Angiology, and Intensive Care Medicine, RWTH Aachen University, University Hospital Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Mulvagh+SL%22">Mulvagh SL</searchLink>; Division of Cardiology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Inzucchi+SE%22">Inzucchi SE</searchLink>; Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Mann+JFE%22">Mann JFE</searchLink>; KfH Kidney Center, Munich, Germany.; Friedrich Alexander University of Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Emerson+SS%22">Emerson SS</searchLink>; Department of Biostatistics, School of Public Health, University of Washington, Seattle.<br /><searchLink fieldCode="AU" term="%22Poulter+NR%22">Poulter NR</searchLink>; Imperial Clinical Trials Unit, Faculty of Medicine, Imperial College London, London, England, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Engelmann+MDM%22">Engelmann MDM</searchLink>; Novo Nordisk A/S, Søborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Hovingh+GK%22">Hovingh GK</searchLink>; Novo Nordisk A/S, Søborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Bayer+Tanggaard+K%22">Bayer Tanggaard K</searchLink>; Novo Nordisk A/S, Søborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Birkenfeld+AL%22">Birkenfeld AL</searchLink>; Department of Diabetology, Endocrinology and Nephrology, University Hospital Tübingen, Tübingen, Germany.; Institute for Diabetes Research and Metabolic Diseases of Helmholtz Munich, Eberhard Karls University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Connelly+KA%22">Connelly KA</searchLink>; Keenan Research Centre for Biomedical Science, Departments of Medicine and Cardiology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Haluzik+M%22">Haluzik M</searchLink>; Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czechia.<br /><searchLink fieldCode="AU" term="%22Cavender+MA%22">Cavender MA</searchLink>; University of North Carolina School of Medicine, Chapel Hill.<br /><searchLink fieldCode="AU" term="%22Kellerer+M%22">Kellerer M</searchLink>; Department of Diabetology and Endocrinology, Clinic for Internal Medicine, Marienhospital Stuttgart, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Jhund+PS%22">Jhund PS</searchLink>; British Heart Foundation Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gregersen+S%22">Gregersen S</searchLink>; Steno Diabetes Center Aarhus, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Nielsen+OW%22">Nielsen OW</searchLink>; Novo Nordisk A/S, Søborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Lam+CSP%22">Lam CSP</searchLink>; National Heart Centre Singapore, Outram, Singapore.; Duke-National University of Singapore, Outram, Singapore.<br /><searchLink fieldCode="AU" term="%22McGuire+DK%22">McGuire DK</searchLink>; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Parkland Health System, Dallas.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101589534 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2168-6114 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221686106%22">21686106 </searchLink><i>NLM ISO Abbreviation: </i>JAMA Intern Med <i>Subsets: </i>MEDLINE
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