Untargeted 1H NMR-based metabolomics unveils distinct circulating biochemical signatures between treatment-resistant and non-treatment-resistant schizophrenia patients: a pilot study.

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Title: Untargeted 1H NMR-based metabolomics unveils distinct circulating biochemical signatures between treatment-resistant and non-treatment-resistant schizophrenia patients: a pilot study.
Authors: Marino C; Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy., Zhang S; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Naples, Italy., De Simone G; Section of Psychiatry, Laboratory of Translational and Molecular Psychiatry and Unit of Treatment-Resistant Psychosis, Department of Neuroscience, Reproductive Sciences and Odontostomatology, University Medical School of Naples 'Federico II', Naples, Italy., Grimaldi M; Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy., Di Maio A; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Naples, Italy.; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università degli Studi della Campania 'Luigi Vanvitelli', Caserta, Italy., Iasevoli F; Section of Psychiatry, Laboratory of Translational and Molecular Psychiatry and Unit of Treatment-Resistant Psychosis, Department of Neuroscience, Reproductive Sciences and Odontostomatology, University Medical School of Naples 'Federico II', Naples, Italy., Errico F; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Naples, Italy.; Department of Agricultural Sciences, University of Naples 'Federico II', Portici, Italy., D'Ursi AM; Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy., de Bartolomeis A; Section of Psychiatry, Laboratory of Translational and Molecular Psychiatry and Unit of Treatment-Resistant Psychosis, Department of Neuroscience, Reproductive Sciences and Odontostomatology, University Medical School of Naples 'Federico II', Naples, Italy. adebarto@unina.it., Usiello A; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Naples, Italy. alessandro.usiello@unicampania.it.; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università degli Studi della Campania 'Luigi Vanvitelli', Caserta, Italy. alessandro.usiello@unicampania.it.
Source: Translational psychiatry [Transl Psychiatry] 2026 Feb 02; Vol. 16 (1). Date of Electronic Publication: 2026 Feb 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2158-3188
DOI:10.1038/s41398-026-03853-6