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Transient acute neuronal activation response caused by high concentrations of oligonucleotides in the cerebral spinal fluid.

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Title: Transient acute neuronal activation response caused by high concentrations of oligonucleotides in the cerebral spinal fluid.
Authors: Bravo-Hernandez M; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Mazur C; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Chen H; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Fradkin L; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Searcy J; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Burel S; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Kelly M; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Bruening D; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., O'Rourke JG; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Cai Y; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Nguyen J; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Berman-Booty L; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Cummins L; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Gaus H; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Powers B; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Zhao HT; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Jafar-Nejad P; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Henry S; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Swayze EE; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States., Kordasiewicz HB; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.
Source: Nucleic acids research [Nucleic Acids Res] 2026 Jan 22; Vol. 54 (3).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Transient acute neuronal activation response caused by high concentrations of oligonucleotides in the cerebral spinal fluid.
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  Data: <searchLink fieldCode="AU" term="%22Bravo-Hernandez+M%22">Bravo-Hernandez M</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Mazur+C%22">Mazur C</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Fradkin+L%22">Fradkin L</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Searcy+J%22">Searcy J</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Burel+S%22">Burel S</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Kelly+M%22">Kelly M</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Bruening+D%22">Bruening D</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22O'Rourke+JG%22">O'Rourke JG</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Nguyen+J%22">Nguyen J</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Berman-Booty+L%22">Berman-Booty L</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Cummins+L%22">Cummins L</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Gaus+H%22">Gaus H</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Powers+B%22">Powers B</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Zhao+HT%22">Zhao HT</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Jafar-Nejad+P%22">Jafar-Nejad P</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Henry+S%22">Henry S</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Swayze+EE%22">Swayze EE</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.<br /><searchLink fieldCode="AU" term="%22Kordasiewicz+HB%22">Kordasiewicz HB</searchLink>; Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.
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