BCAT1-elicited branched-chain amino acid catabolism fosters neutrophil-mediated pan-metastasis in pancreatic cancer.

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Title: BCAT1-elicited branched-chain amino acid catabolism fosters neutrophil-mediated pan-metastasis in pancreatic cancer.
Authors: Xie F; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Department of Pancreaticobiliary Surgery, Sun Yat-sen University Cancer Center, Guangzhou 510060, China., Ren YZ; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China., Jian ZW; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Department of Pancreaticobiliary Surgery, Sun Yat-sen University Cancer Center, Guangzhou 510060, China., Peng JY; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Department of Pancreaticobiliary Surgery, Sun Yat-sen University Cancer Center, Guangzhou 510060, China., Jiang HF; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China., Lu YM; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China., Zhang C; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China., Li ZQ; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China., Zhang QR; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China., Cui JJ; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China., Wu RQ; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China., Bei JX; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China; Institute of Advanced Studies Hong Kong, Sun Yat-sen University, Hong Kong Science Park, Hong Kong SAR, China; Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing 211166, China., Wei Y; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China., Kuang DM; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China; Institute of Advanced Studies Hong Kong, Sun Yat-sen University, Hong Kong Science Park, Hong Kong SAR, China; Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing 211166, China. Electronic address: kdming@mail.sysu.edu.cn., Xu J; Department of Oncology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China. Electronic address: xujunying@wuxiph.com., Lao XM; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Department of Pancreaticobiliary Surgery, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. Electronic address: laoxm@sysucc.org.cn.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 May 06; Vol. 34 (5), pp. 3097-3111. Date of Electronic Publication: 2026 Feb 02.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2026.01.039