Chimeric antigen receptor T cells against the IGHV4-34 B cell receptor specifically eliminate neoplastic and autoimmune B cells.
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| Title: | Chimeric antigen receptor T cells against the IGHV4-34 B cell receptor specifically eliminate neoplastic and autoimmune B cells. |
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| Authors: | Cohen IJ; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Bochi-Layec AC; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Lemoine J; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Jenks S; Department of Medicine, Division of Rheumatology, School of Medicine, Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322, USA., Bayat P; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Kim KH; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Zhao H; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Surgery, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Ugwuanyi O; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Stella F; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Ghilardi G; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Gabrielli G; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., McCuaig S; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Iatrou A; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki 57001, Greece., Vlachonikola E; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki 57001, Greece., Karipidou M; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki 57001, Greece., Bouziani E; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Espie D; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Ramasubramanian R; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Agathangelidis A; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki 57001, Greece.; Division of Genetics and Biotechnology, Department of Biology, National and Kapodistrian University of Athens, Athens 15772, Greece., Bhosale A; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Paruzzo L; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Medico G; Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, NY 10065, USA., Kolar B; LatchBio, San Francisco, CA 94107, USA., Bugrovsky R; Department of Medicine, Division of Rheumatology, School of Medicine, Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322, USA., Guruprasad P; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Wang LP; Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine and Therapeutic Pathology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Harris J; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine and Therapeutic Pathology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Arons E; Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Zhang Y; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Pajarillo R; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Kreiger PA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Day CP; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Sahinalp SC; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Wu CH; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Santi A; Institute of Hematology and Center for Hemato-Oncology Research, Department of Medicine and Surgery, University and Hospital of Perugia, Perugia 06129, Italy., Fulmer B; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Cases M; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine and Therapeutic Pathology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Palmer MB; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Porazzi P; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Wherry EJ; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Kreitman RJ; Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Tiacci E; Institute of Hematology and Center for Hemato-Oncology Research, Department of Medicine and Surgery, University and Hospital of Perugia, Perugia 06129, Italy., Apostolidis SA; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Behrens EM; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Bhoj V; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine and Therapeutic Pathology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Sanz I; Department of Medicine, Division of Rheumatology, School of Medicine, Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322, USA., Inghirami G; Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, NY 10065, USA., Schuster SJ; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA., Ghia P; Medical School, Università Vita-Salute San Raffaele, Milan 20132, Italy.; B cell Neoplasia Unit, Comprehensive Cancer Center, IRCCS Ospedale San Raffaele, Milan 20132, Italy., Stamatopoulos K; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki 57001, Greece., Ruella M; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Hematology/Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2026 Feb 04; Vol. 18 (835), pp. eadr9382. Date of Electronic Publication: 2026 Feb 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adr9382 |
