Enhancing CAR- and TCR-mediated targeting of cancer via an immune synapse-stabilizing receptor.

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Title: Enhancing CAR- and TCR-mediated targeting of cancer via an immune synapse-stabilizing receptor.
Authors: Tsai CT; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Ibanez-Vega J; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA., Yin P; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA., Teis R; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.; St. Jude Graduate School of Biomedical Sciences, Memphis, TN, USA., Watanabe N; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA., Honda T; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA., Valkov M; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA., Chockley PJ; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.; The Molecular Medicine and Therapeutics Department, The Ohio State University College of Medicine, Columbus, OH, USA., Madrigal LAJ; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA., Krenciute G; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA., Mamonkin M; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA. mm6947@cumc.columbia.edu.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. mm6947@cumc.columbia.edu.; Columbia Initiative in Cell Therapy and Engineering, Department of Pediatrics, Columbia University, New York, NY, USA. mm6947@cumc.columbia.edu.
Source: Nature communications [Nat Commun] 2026 Feb 04; Vol. 17 (1), pp. 1349. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-65897-4