Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.

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Title: Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.
Authors: White SL; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Brasher MS; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Pattee J; Center for Innovative Design & Analysis, Colorado School of Public Health, University of Colorado Anschutz, Aurora, CO, USA., Zhou W; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Chapman S; The Broad Institute, Cambridge, MA, USA., Jee YH; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Bell CC; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA., Jamil TL; Department of Otolaryngology, Head and Neck Surgery, University of Colorado Anschutz, Aurora, CO, USA., Barrio M; Division of GI, Trauma, and Endocrine Surgery, Department of Surgery, University of Colorado Anschutz, Aurora, CO, USA., Arehart CH; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Ecology & Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA., Evans LM; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Ecology & Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA., Hirbo J; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Cox NJ; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Straub P; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Namba S; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Bertucci-Richter E; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Guare L; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Edris A; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Morris S; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Mulford AJ; Genomic Health Initiative, Endeavor Health Research Institute, Evanston, IL, USA., Zhang H; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Fennessy B; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tobin MD; Division of Public Health and Epidemiology, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Chen J; Division of Public Health and Epidemiology, University of Leicester, Leicester, UK., Williams AT; Division of Public Health and Epidemiology, University of Leicester, Leicester, UK., John C; Division of Public Health and Epidemiology, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., van Heel DA; Blizard Institute, Queen Mary University of London, London, UK., Mathur R; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Finer S; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Moksnes MR; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Brumpton BM; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Åsvold BO; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Peculis R; Latvian Biomedical Research and Study Centre, Riga, Latvia., Rovite V; Latvian Biomedical Research and Study Centre, Riga, Latvia., Konrade I; Department of Internal Medicine, Riga Stradins University, Riga, Latvia., Wang Y; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Crooks K; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA., Chavan S; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA., Fisher MJ; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA., Rafaels N; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA., Lin M; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA., Shortt JA; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA., Sanders AR; Genomic Health Initiative, Endeavor Health Research Institute, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA., Whiteman DC; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., MacGregor S; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Medland SE; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Thorsteinsdóttir U; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Stefánsson K; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Karaderi T; Department of Public Health, Faculty of Health and Medical Sciences, Center for Health Data Science, Section for Health Data Science and Artificial Intelligence, University of Copenhagen, Copenhagen, Denmark., Egan KM; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Bocklage T; University of Kentucky Markey Cancer Center, Lexington, KY, USA.; University of Kentucky-Department of Pathology and Laboratory Medicine, University of Kentucky-Chandler Medical Center, Lexington, KY, USA., McCrary HC; University of Utah Huntsman Cancer Institute, Salt Lake City, UT, USA.; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Riedlinger G; Rutgers Cancer Institute, New Brunswick, NJ, USA., Salhia B; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Shriver C; Murtha Cancer Center, Uniformed Services University/Walter Reed National Military Medical Center, Bethesda, MD, USA., Phan MD; University of Oklahoma Stephenson Cancer Center, Oklahoma City, OK, USA.; Medical Oncology/Head and Neck Oncology, Stephenson Cancer Center, University of Oklahoma, Oklahoma City, OK, USA., Farlow JL; Indiana University School of Medicine, Indianapolis, IN, USA., Edge S; Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Departments of Surgical Oncology and Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Kaur V; University of Virginia Cancer Center, Charlottesville, VA, USA.; Department of Internal Medicine, Division of Hematology & Oncology, University of Virginia Health, Charlottesville, VA, USA., Churchman ML; Aster Insights, Hudson, FL, USA., Rounbehler RJ; Aster Insights, Hudson, FL, USA., Brock PL; The Ohio State University Comprehensive Cancer Center and the Ohio State University College of Medicine, Columbus, OH, USA., Ringel MD; The Ohio State University Comprehensive Cancer Center and the Ohio State University College of Medicine, Columbus, OH, USA.; Department of Molecular Medicine and Therapeutics, The Ohio State University Comprehensive Cancer Center and the Ohio State University College of Medicine, Columbus, OH, USA., Pividori M; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz, Aurora, CO, USA., Schweppe R; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA., Raeburn CD; Division of GI, Trauma, and Endocrine Surgery, Department of Surgery, University of Colorado Anschutz, Aurora, CO, USA., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China.; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China., Matsuda K; Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Okada Y; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Zöllner S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Verma A; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kenny E; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hendricks AE; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Fishbein L; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA.; Research Service, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Transdivisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Daly MJ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Neale BM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Martin AR; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Cole JB; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz, Aurora, CO, USA., Haugen BR; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA., Gignoux CR; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA. chris.gignoux@cuanschutz.edu.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA. chris.gignoux@cuanschutz.edu.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz, Aurora, CO, USA. chris.gignoux@cuanschutz.edu.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA. chris.gignoux@cuanschutz.edu., Pozdeyev N; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA. nikita.pozdeyev@cuanschutz.edu.; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA. nikita.pozdeyev@cuanschutz.edu.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA. nikita.pozdeyev@cuanschutz.edu.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA. nikita.pozdeyev@cuanschutz.edu.
Corporate Authors: Penn Medicine BioBank, Virtual Thyroid Biopsy Consortium, Colorado Center for Personalized Medicine, Genes & Health Research Team, BioBank Japan Project, Global Biobank Meta-analysis Initiative
Source: Nature genetics [Nat Genet] 2026 Feb; Vol. 58 (2), pp. 307-316. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-1718
DOI:10.1038/s41588-025-02483-w