Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.
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| Title: | Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases. |
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| Authors: | White SL; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Brasher MS; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Pattee J; Center for Innovative Design & Analysis, Colorado School of Public Health, University of Colorado Anschutz, Aurora, CO, USA., Zhou W; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Chapman S; The Broad Institute, Cambridge, MA, USA., Jee YH; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Bell CC; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA., Jamil TL; Department of Otolaryngology, Head and Neck Surgery, University of Colorado Anschutz, Aurora, CO, USA., Barrio M; Division of GI, Trauma, and Endocrine Surgery, Department of Surgery, University of Colorado Anschutz, Aurora, CO, USA., Arehart CH; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Ecology & Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA., Evans LM; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Ecology & Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA., Hirbo J; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Cox NJ; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Straub P; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Namba S; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Bertucci-Richter E; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Guare L; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Edris A; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Morris S; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Mulford AJ; Genomic Health Initiative, Endeavor Health Research Institute, Evanston, IL, USA., Zhang H; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Fennessy B; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tobin MD; Division of Public Health and Epidemiology, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Chen J; Division of Public Health and Epidemiology, University of Leicester, Leicester, UK., Williams AT; Division of Public Health and Epidemiology, University of Leicester, Leicester, UK., John C; Division of Public Health and Epidemiology, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., van Heel DA; Blizard Institute, Queen Mary University of London, London, UK., Mathur R; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Finer S; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Moksnes MR; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Brumpton BM; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Åsvold BO; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Peculis R; Latvian Biomedical Research and Study Centre, Riga, Latvia., Rovite V; Latvian Biomedical Research and Study Centre, Riga, Latvia., Konrade I; Department of Internal Medicine, Riga Stradins University, Riga, Latvia., Wang Y; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Crooks K; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA., Chavan S; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA., Fisher MJ; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA., Rafaels N; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA., Lin M; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA., Shortt JA; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA., Sanders AR; Genomic Health Initiative, Endeavor Health Research Institute, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA., Whiteman DC; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., MacGregor S; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Medland SE; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Thorsteinsdóttir U; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Stefánsson K; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Karaderi T; Department of Public Health, Faculty of Health and Medical Sciences, Center for Health Data Science, Section for Health Data Science and Artificial Intelligence, University of Copenhagen, Copenhagen, Denmark., Egan KM; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Bocklage T; University of Kentucky Markey Cancer Center, Lexington, KY, USA.; University of Kentucky-Department of Pathology and Laboratory Medicine, University of Kentucky-Chandler Medical Center, Lexington, KY, USA., McCrary HC; University of Utah Huntsman Cancer Institute, Salt Lake City, UT, USA.; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Riedlinger G; Rutgers Cancer Institute, New Brunswick, NJ, USA., Salhia B; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Shriver C; Murtha Cancer Center, Uniformed Services University/Walter Reed National Military Medical Center, Bethesda, MD, USA., Phan MD; University of Oklahoma Stephenson Cancer Center, Oklahoma City, OK, USA.; Medical Oncology/Head and Neck Oncology, Stephenson Cancer Center, University of Oklahoma, Oklahoma City, OK, USA., Farlow JL; Indiana University School of Medicine, Indianapolis, IN, USA., Edge S; Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Departments of Surgical Oncology and Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Kaur V; University of Virginia Cancer Center, Charlottesville, VA, USA.; Department of Internal Medicine, Division of Hematology & Oncology, University of Virginia Health, Charlottesville, VA, USA., Churchman ML; Aster Insights, Hudson, FL, USA., Rounbehler RJ; Aster Insights, Hudson, FL, USA., Brock PL; The Ohio State University Comprehensive Cancer Center and the Ohio State University College of Medicine, Columbus, OH, USA., Ringel MD; The Ohio State University Comprehensive Cancer Center and the Ohio State University College of Medicine, Columbus, OH, USA.; Department of Molecular Medicine and Therapeutics, The Ohio State University Comprehensive Cancer Center and the Ohio State University College of Medicine, Columbus, OH, USA., Pividori M; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz, Aurora, CO, USA., Schweppe R; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA., Raeburn CD; Division of GI, Trauma, and Endocrine Surgery, Department of Surgery, University of Colorado Anschutz, Aurora, CO, USA., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China.; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China., Matsuda K; Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Okada Y; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Zöllner S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Verma A; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kenny E; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hendricks AE; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Fishbein L; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA.; Research Service, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Transdivisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Daly MJ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Neale BM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Martin AR; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Cole JB; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz, Aurora, CO, USA., Haugen BR; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA., Gignoux CR; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA. chris.gignoux@cuanschutz.edu.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA. chris.gignoux@cuanschutz.edu.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz, Aurora, CO, USA. chris.gignoux@cuanschutz.edu.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA. chris.gignoux@cuanschutz.edu., Pozdeyev N; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA. nikita.pozdeyev@cuanschutz.edu.; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA. nikita.pozdeyev@cuanschutz.edu.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA. nikita.pozdeyev@cuanschutz.edu.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA. nikita.pozdeyev@cuanschutz.edu. |
| Corporate Authors: | Penn Medicine BioBank, Virtual Thyroid Biopsy Consortium, Colorado Center for Personalized Medicine, Genes & Health Research Team, BioBank Japan Project, Global Biobank Meta-analysis Initiative |
| Source: | Nature genetics [Nat Genet] 2026 Feb; Vol. 58 (2), pp. 307-316. Date of Electronic Publication: 2026 Feb 05. |
| Publication Type: | Journal Article; Meta-Analysis |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41644669 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22White+SL%22">White SL</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Brasher+MS%22">Brasher MS</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Pattee+J%22">Pattee J</searchLink>; Center for Innovative Design & Analysis, Colorado School of Public Health, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chapman+S%22">Chapman S</searchLink>; The Broad Institute, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jee+YH%22">Jee YH</searchLink>; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bell+CC%22">Bell CC</searchLink>; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Jamil+TL%22">Jamil TL</searchLink>; Department of Otolaryngology, Head and Neck Surgery, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Barrio+M%22">Barrio M</searchLink>; Division of GI, Trauma, and Endocrine Surgery, Department of Surgery, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Arehart+CH%22">Arehart CH</searchLink>; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Ecology & Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22Evans+LM%22">Evans LM</searchLink>; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Ecology & Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22Hirbo+J%22">Hirbo J</searchLink>; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cox+NJ%22">Cox NJ</searchLink>; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Straub+P%22">Straub P</searchLink>; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Namba+S%22">Namba S</searchLink>; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Bertucci-Richter+E%22">Bertucci-Richter E</searchLink>; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Guare+L%22">Guare L</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Edris+A%22">Edris A</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Morris+S%22">Morris S</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mulford+AJ%22">Mulford AJ</searchLink>; Genomic Health Initiative, Endeavor Health Research Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Fennessy+B%22">Fennessy B</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tobin+MD%22">Tobin MD</searchLink>; Division of Public Health and Epidemiology, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Division of Public Health and Epidemiology, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Williams+AT%22">Williams AT</searchLink>; Division of Public Health and Epidemiology, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22John+C%22">John C</searchLink>; Division of Public Health and Epidemiology, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22van+Heel+DA%22">van Heel DA</searchLink>; Blizard Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Mathur+R%22">Mathur R</searchLink>; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Finer+S%22">Finer S</searchLink>; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Moksnes+MR%22">Moksnes MR</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.<br /><searchLink fieldCode="AU" term="%22Brumpton+BM%22">Brumpton BM</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Åsvold+BO%22">Åsvold BO</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Peculis+R%22">Peculis R</searchLink>; Latvian Biomedical Research and Study Centre, Riga, Latvia.<br /><searchLink fieldCode="AU" term="%22Rovite+V%22">Rovite V</searchLink>; Latvian Biomedical Research and Study Centre, Riga, Latvia.<br /><searchLink fieldCode="AU" term="%22Konrade+I%22">Konrade I</searchLink>; Department of Internal Medicine, Riga Stradins University, Riga, Latvia.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Crooks+K%22">Crooks K</searchLink>; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Chavan+S%22">Chavan S</searchLink>; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Fisher+MJ%22">Fisher MJ</searchLink>; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Rafaels+N%22">Rafaels N</searchLink>; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Lin+M%22">Lin M</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Shortt+JA%22">Shortt JA</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Sanders+AR%22">Sanders AR</searchLink>; Genomic Health Initiative, Endeavor Health Research Institute, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Whiteman+DC%22">Whiteman DC</searchLink>; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22MacGregor+S%22">MacGregor S</searchLink>; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Medland+SE%22">Medland SE</searchLink>; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Thorsteinsdóttir+U%22">Thorsteinsdóttir U</searchLink>; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Stefánsson+K%22">Stefánsson K</searchLink>; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Karaderi+T%22">Karaderi T</searchLink>; Department of Public Health, Faculty of Health and Medical Sciences, Center for Health Data Science, Section for Health Data Science and Artificial Intelligence, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Egan+KM%22">Egan KM</searchLink>; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Bocklage+T%22">Bocklage T</searchLink>; University of Kentucky Markey Cancer Center, Lexington, KY, USA.; University of Kentucky-Department of Pathology and Laboratory Medicine, University of Kentucky-Chandler Medical Center, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22McCrary+HC%22">McCrary HC</searchLink>; University of Utah Huntsman Cancer Institute, Salt Lake City, UT, USA.; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Riedlinger+G%22">Riedlinger G</searchLink>; Rutgers Cancer Institute, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Salhia+B%22">Salhia B</searchLink>; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shriver+C%22">Shriver C</searchLink>; Murtha Cancer Center, Uniformed Services University/Walter Reed National Military Medical Center, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Phan+MD%22">Phan MD</searchLink>; University of Oklahoma Stephenson Cancer Center, Oklahoma City, OK, USA.; Medical Oncology/Head and Neck Oncology, Stephenson Cancer Center, University of Oklahoma, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Farlow+JL%22">Farlow JL</searchLink>; Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Edge+S%22">Edge S</searchLink>; Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Departments of Surgical Oncology and Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kaur+V%22">Kaur V</searchLink>; University of Virginia Cancer Center, Charlottesville, VA, USA.; Department of Internal Medicine, Division of Hematology & Oncology, University of Virginia Health, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Churchman+ML%22">Churchman ML</searchLink>; Aster Insights, Hudson, FL, USA.<br /><searchLink fieldCode="AU" term="%22Rounbehler+RJ%22">Rounbehler RJ</searchLink>; Aster Insights, Hudson, FL, USA.<br /><searchLink fieldCode="AU" term="%22Brock+PL%22">Brock PL</searchLink>; The Ohio State University Comprehensive Cancer Center and the Ohio State University College of Medicine, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Ringel+MD%22">Ringel MD</searchLink>; The Ohio State University Comprehensive Cancer Center and the Ohio State University College of Medicine, Columbus, OH, USA.; Department of Molecular Medicine and Therapeutics, The Ohio State University Comprehensive Cancer Center and the Ohio State University College of Medicine, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Pividori+M%22">Pividori M</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Schweppe+R%22">Schweppe R</searchLink>; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Raeburn+CD%22">Raeburn CD</searchLink>; Division of GI, Trauma, and Endocrine Surgery, Department of Surgery, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Walters+RG%22">Walters RG</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China.; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Matsuda+K%22">Matsuda K</searchLink>; Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Okada+Y%22">Okada Y</searchLink>; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Zöllner+S%22">Zöllner S</searchLink>; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Verma+A%22">Verma A</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Preuss+MH%22">Preuss MH</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kenny+E%22">Kenny E</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hendricks+AE%22">Hendricks AE</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Fishbein+L%22">Fishbein L</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA.; Research Service, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Kraft+P%22">Kraft P</searchLink>; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Transdivisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Daly+MJ%22">Daly MJ</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Neale+BM%22">Neale BM</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Martin+AR%22">Martin AR</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cole+JB%22">Cole JB</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Haugen+BR%22">Haugen BR</searchLink>; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Gignoux+CR%22">Gignoux CR</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA. chris.gignoux@cuanschutz.edu.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA. chris.gignoux@cuanschutz.edu.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz, Aurora, CO, USA. chris.gignoux@cuanschutz.edu.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA. chris.gignoux@cuanschutz.edu.<br /><searchLink fieldCode="AU" term="%22Pozdeyev+N%22">Pozdeyev N</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA. nikita.pozdeyev@cuanschutz.edu.; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA. nikita.pozdeyev@cuanschutz.edu.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA. nikita.pozdeyev@cuanschutz.edu.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA. nikita.pozdeyev@cuanschutz.edu. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22Penn+Medicine+BioBank%22">Penn Medicine BioBank</searchLink><br /><searchLink fieldCode="CA" term="%22Virtual+Thyroid+Biopsy+Consortium%22">Virtual Thyroid Biopsy Consortium</searchLink><br /><searchLink fieldCode="CA" term="%22Colorado+Center+for+Personalized+Medicine%22">Colorado Center for Personalized Medicine</searchLink><br /><searchLink fieldCode="CA" term="%22Genes+%26+Health+Research+Team%22">Genes & Health Research Team</searchLink><br /><searchLink fieldCode="CA" term="%22BioBank+Japan+Project%22">BioBank Japan Project</searchLink><br /><searchLink fieldCode="CA" term="%22Global+Biobank+Meta-analysis+Initiative%22">Global Biobank Meta-analysis Initiative</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2026 Feb; Vol. 58 (2), pp. 307-316. <i>Date of Electronic Publication: </i>2026 Feb 05. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Meta-Analysis – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Co%22">Nature Pub. Co </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9216904 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1718 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210614036%22">10614036 </searchLink><i>NLM ISO Abbreviation: </i>Nat Genet <i>Subsets: </i>MEDLINE |
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