The protective effect of ambroxol against cyclophosphamide-induced acute kidney injury involves Nrf2/HO-1 signaling upregulation and suppression of oxidative and inflammatory damage.
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| Title: | The protective effect of ambroxol against cyclophosphamide-induced acute kidney injury involves Nrf2/HO-1 signaling upregulation and suppression of oxidative and inflammatory damage. |
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| Authors: | Alruhaimi RS; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, 11671, Saudi Arabia., Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt. emadhassanien@azhar.edu.eg., Alnasser SM; Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, 52571, Saudi Arabia., Althagafy HS; Division of Biochemistry, Department of Biological Sciences, Faculty of Science, University of Jeddah, Jeddah, 21589, Saudi Arabia., Sabry M; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt., Ahmed AA; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt., Mahmoud AM; Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, M1 5GD, UK. a.mahmoud@mmu.ac.uk. |
| Source: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Apr; Vol. 399 (7), pp. 10599-10614. Date of Electronic Publication: 2026 Feb 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1432-1912 |
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| DOI: | 10.1007/s00210-025-04919-w |
