Genetic risk factors modulate the association between physical activity and colorectal cancer.

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Title: Genetic risk factors modulate the association between physical activity and colorectal cancer.
Authors: Peoples AR; Huntsman Cancer Institute, Salt Lake City, UT, USA.; Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.; Department of Population Science, American Cancer Society, Atlanta, GA, USA., Obón-Santacana M; Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, 08908, Spain.; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08908, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, 28029, Spain., Kim AE; Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Kawaguchi ES; Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Fu Y; Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Qu C; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Moratalla-Navarro F; Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, 08908, Spain.; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08908, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, 28029, Spain.; Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, 08908, Spain., Morrison J; Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Lin Y; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Arndt V; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Bien SA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Bishop DT; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK., Bouras E; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Buchanan DD; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, VIC, Australia., Campbell PT; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Chan AT; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany., Conti DV; Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Corley DA; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.; Department of Gastroenterology, Kaiser Permanente Medical Center, San Francisco, CA, USA., Devall MA; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, Center for Public Health Genomics, Charlottesville, VA, USA., Dimou N; Nutrition and Metabolism Branch, International Agency for Research On Cancer, World Health Organization, Lyon, France., Drew DA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Gruber SB; Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.; Center for Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA., Gunter MJ; Nutrition and Metabolism Branch, International Agency for Research On Cancer, World Health Organization, Lyon, France.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Harlid S; Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden., Harrison TA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Hoffmeister M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Huyghe JR; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Keku TO; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA., Kundaje A; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Lewinger JP; Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Li L; Department of Family Medicine, University of Virginia, Charlottesville, VA, USA.; UVA Comprehensive Cancer Center, University of Virginia, Charlottesville, VA, USA., Lynch BM; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia., Le Marchand L; University of Hawaii Cancer Center, Honolulu, HI, USA., Martín V; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, 28029, Spain.; The Research Group in Gene - Environment and Health Interactions (GIIGAS), Institut of Biomedicine (IBIOMED), Universidad de León, León, 24071, Spain.; Faculty of Health Sciences, Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Universidad de León, León, 24071, Spain., Murphy N; Nutrition and Metabolism Branch, International Agency for Research On Cancer, World Health Organization, Lyon, France., Newton CC; Department of Population Science, American Cancer Society, Atlanta, GA, USA., Ogino S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Hardikar S; Huntsman Cancer Institute, Salt Lake City, UT, USA.; Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA., Ose J; Huntsman Cancer Institute, Salt Lake City, UT, USA.; Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.; Department of Media, Information, and Design, University of Applied Sciences and Arts, Hannover, Germany., Pai RK; Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA., Palmer JR; Slone Epidemiology Center at Boston University, Boston, MA, USA., Papadimitriou N; Nutrition and Metabolism Branch, International Agency for Research On Cancer, World Health Organization, Lyon, France., Pardamean B; Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia., Pellatt AJ; Department of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pinchev M; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel., Platz EA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Potter JD; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand.; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA., Rennert G; Technion-Israel Institute of Technology and APRPM, Haifa, Israel.; Clalit National Cancer Control Center, Haifa, Israel., Ruiz-Narvaez EA; Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA., Sakoda LC; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Schoen RE; Departments of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Shcherbina A; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Stern MC; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Su YR; Biostatistics Division, Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Thomas CE; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Tian Y; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; School of Public Health, Capital Medical University, Beijing, China., Tsilidis KK; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Um CY; Department of Population Science, American Cancer Society, Atlanta, GA, USA., van Duijnhoven FJB; Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands., Van Guelpen B; Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.; Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden., Visvanathan K; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Wang J; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., White E; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel., Wolk A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Woods MO; Division of Biomedical Sciences, Memorial University of Newfoundland, St. John's, Canada., Wu AH; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Ulrich CM; Huntsman Cancer Institute, Salt Lake City, UT, USA. neli.ulrich@hci.utah.edu.; Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA. neli.ulrich@hci.utah.edu., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. upeters@fredhutch.org.; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA. upeters@fredhutch.org., Gauderman WJ; Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. jimg@usc.edu., Moreno V; Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, 08908, Spain. v.moreno@iconcologia.net.; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08908, Spain. v.moreno@iconcologia.net.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, 28029, Spain. v.moreno@iconcologia.net.; Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, 08908, Spain. v.moreno@iconcologia.net.
Source: BMC medicine [BMC Med] 2026 Feb 05; Vol. 24 (1). Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1741-7015
DOI:10.1186/s12916-026-04675-5