EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration.

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Title: EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration.
Authors: Qiu S; Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China., Xu W; Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China., Yu C; Department of Orthopedics, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610031, China., Cen S; Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China., Duan Y; Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China., Li J; Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China., Chen X; Department of Pharmacy, School of Medicine, The Sixth Affiliated Hospital, South China University of Technology, Foshan, 528200, China., Lan T; Department of Spine Surgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China., Liu C; Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. 975529339@qq.com., Zheng Y; Department of Spine Surgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China. chinazuc@163.com.
Source: Cell biology and toxicology [Cell Biol Toxicol] 2026 Feb 07; Vol. 42 (1), pp. 37. Date of Electronic Publication: 2026 Feb 07.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 8506639 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6822 (Electronic) Linking ISSN: 07422091 NLM ISO Abbreviation: Cell Biol Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1573-6822
DOI:10.1007/s10565-026-10162-7