Age and onset timing of Raynaud's phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italian Society for Rheumatology (SPRING-SIR).
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| Title: | Age and onset timing of Raynaud's phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italian Society for Rheumatology (SPRING-SIR). |
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| Authors: | Peretti S; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy., Bruni C; Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich 8091, Switzerland.; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Bonomi F; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy., De Angelis R; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy., Bajocchi G; Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia, Italy., Giuggioli D; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., Orlandi M; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., Zanframundo G; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Foti R; Rheumatology Unit, AOU Policlinico San Marco, Catania, Italy., Visalli E; Rheumatology Unit, AOU Policlinico San Marco, Catania, Italy., Cuomo G; Department of Precision Medicine, University of Campania-Luigi Vanvitelli University, Naples, Italy., Ariani A; Department of Medicine, Internal Medicine and Rheumatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy., Rosato E; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Lepri G; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy., Girelli F; Department of Medicine, Rheumatology Unit, Ospedale GB Morgagni-L Pierantoni, Forlì, Italy., Riccieri V; Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy., Zanatta E; Department of Rheumatology, University of Padua, Padova, Italy., Bosello SL; Rheumatology Division, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy., Cavazzana I; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Ingegnoli F; Clinica Reumatologica, Dipartimento di Reumatologia e Scienze Mediche, ASST Gaetano Pini-CTO, Dipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza, Università degli Studi di Milano, Milan, Italy., De Santis M; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan and Research Hospital, Milan, Italy., Cacciapaglia F; Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari 'Aldo Moro,' Bari, Italy.; Rheumatology Service, Internal Medicine Unit 'F. Miulli' General Hospital, Acquaviva delle Fonti, Bari, Italy.; Department of Medicine and Surgery, LUM 'G. De Gennaro,' Casamassima, Bari, Italy., Murdaca G; Department of Internal Medicine, University of Genoa and Allergology, and Clinical Immunology Unit, Ospedale San Bartolomeo, Sarzana, Italy., Abignano G; Rheumatology Unit, Department of Health Science, San Carlo Hospital, University of Basilicata, Potenza, Italy., Pettiti G; Rheumatology Unit ASO S., Croce e Carle Hospital, Cuneo, Italy., Della Rossa A; Department of Rheumatology, University of Pisa, Pisa, Italy., Caminiti M; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Iuliano A; Rheumatology Unit, San Camillo-Forlanini Hospital, Rome, Italy., Ciano G; Local Health Department, Hospital of Ariano Irpino, Ariano Irpino, Italy., Beretta L; Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy., Bagnato G; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Lubrano E; Department of Rheumatology, University of Molise, Campobasso, Italy., De Andres I; Rheumatology Unit, Azienda Ospedaliera di Rilievo Nazionale ed Alta Specializzazione Garibaldi, Catania, Italy., Idolazzi L; Rheumatology Unit, Department of Medicine, University of Verona, Verona, Italy., Saracco M; Rheumatology Unit, Mauriziano-Umberto I Hospital, Turin, Italy., Agnes C; Division of Rehabilitation, Department of Medicine, Torino, ASL TO5, Carmagnola, Italy., Campochiaro C; IRCCS San Raffaele Scientific Institute, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, & Inflammation, Fibrosis and Ageing initiative, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., De Luca G; IRCCS San Raffaele Scientific Institute, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, & Inflammation, Fibrosis and Ageing initiative, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Cipolletta E; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy., Fornaro M; Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari 'Aldo Moro,' Bari, Italy., Lumetti F; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., Spinella A; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., Magnani L; Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia, Italy., Codullo V; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Iandoli C; Department of Precision Medicine, University of Campania-Luigi Vanvitelli University, Naples, Italy., Gigante A; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Pellegrino G; Department of Rheumatology, IRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy.; Dipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, Milan, Italy., Pigatto E; Department of Medicine, Villa Salus Hospital, Mestre, Italy., Lazzaroni MG; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., De Lorenzis E; Rheumatology Division, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy., Mennillo GA; Rheumatology Unit, Department of Health Science, San Carlo Hospital, University of Basilicata, Potenza, Italy., Battista MD; Department of Rheumatology, University of Pisa, Pisa, Italy., Pagano Mariano G; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Furini F; Department of Medicine, Villa Salus Hospital, Mestre, Italy., Vultaggio L; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Italy., Parisi S; Rheumatology Unit, Azienda Ospedaliera Universitaria Città Della Salute e della Scienza di Torino, Turin, Italy., Peroni CL; Rheumatology Unit, Azienda Ospedaliera Universitaria Città Della Salute e della Scienza di Torino, Turin, Italy., Bianchi G; Rheumatology Unit, Department of Medical Specialities, Local Health Trust 3, Genoa, Italy., Fusaro E; Rheumatology Unit, Azienda Ospedaliera Universitaria Città Della Salute e della Scienza di Torino, Turin, Italy., Sebastiani GD; Rheumatology Unit, San Camillo-Forlanini Hospital, Rome, Italy., Govoni M; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Italy., D'Angelo S; Rheumatology Unit, Department of Health Science, San Carlo Hospital, University of Basilicata, Potenza, Italy., Cozzi F; Department of Medicine, Villa Salus Hospital, Mestre, Italy., Franceschini F; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Guiducci S; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy., Dagna L; IRCCS San Raffaele Scientific Institute, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, & Inflammation, Fibrosis and Ageing initiative, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Doria A; Department of Rheumatology, University of Padua, Padova, Italy., Salvarani C; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., D'Agostino MA; Rheumatology Division, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy., Iannone F; Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari 'Aldo Moro,' Bari, Italy., Matucci-Cerinic M; IRCCS San Raffaele Scientific Institute, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, & Inflammation, Fibrosis and Ageing initiative, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Ferri C; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy.; Rheumatology Clinic 'Madonna dello Scoglio' Crotonei, Crotone, Italy., Randone SB; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy. |
| Source: | Therapeutic advances in musculoskeletal disease [Ther Adv Musculoskelet Dis] 2026 Feb 05; Vol. 18, pp. 1759720X251410243. Date of Electronic Publication: 2026 Feb 05 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Sage Country of Publication: England NLM ID: 101517322 Publication Model: eCollection Cited Medium: Print ISSN: 1759-720X (Print) Linking ISSN: 1759720X NLM ISO Abbreviation: Ther Adv Musculoskelet Dis Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1759-720X |
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| DOI: | 10.1177/1759720X251410243 |
