Protein-only centromeric chromatin assembly streamlines human artificial chromosome formation.

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Title: Protein-only centromeric chromatin assembly streamlines human artificial chromosome formation.
Authors: Birchak GJ; Department of Biochemistry & Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Penn Center for Genome Integrity, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Graduate Program in Cell & Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA., Allu PK; Department of Biochemistry & Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Penn Center for Genome Integrity, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA., Kashyap P; Department of Biochemistry & Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Penn Center for Genome Integrity, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA., Anbalagan GK; Department of Biochemistry & Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Penn Center for Genome Integrity, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA., Chuang SC; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA., Logsdon GA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Graduate Program in Cell & Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA., Gibson DG; J. Craig Venter Institute, La Jolla, CA 92037 USA., Glass JI; J. Craig Venter Institute, La Jolla, CA 92037 USA., Black BE; Department of Biochemistry & Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Penn Center for Genome Integrity, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.; Graduate Program in Cell & Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 29. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.01.28.702397