Staphylococcal accessory regulator SarA-mediated modulation of autolysis and surface charge enables Staphylococcus aureus to evade vancomycin killing.

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Title: Staphylococcal accessory regulator SarA-mediated modulation of autolysis and surface charge enables Staphylococcus aureus to evade vancomycin killing.
Authors: Li Y; Anhui Province Key Laboratory of Pollution Damage and Biological Control for Huaihe River Basin, School of Biological and Food Engineering, Fuyang Normal University, Fuyang, China.; Anhui Province Key Laboratory of Embryo Development and Reproduction Regulation, School of Biological and Food Engineering, Fuyang Normal University, Fuyang, China.; Anhui Province Key Laboratory of Environmental Hormone and Reproduction, School of Biological and Food Engineering, Fuyang Normal University, Fuyang, China.; State Key Laboratory of Immune Response and Immunotherapy, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China., Yuan S; State Key Laboratory of Immune Response and Immunotherapy, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China., Yan P; State Key Laboratory of Immune Response and Immunotherapy, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China., Zhai S; Huaibei Agricultural Products Quality and Safety Testing Center, Huaibei, Anhui, China., He Z; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Su H; State Key Laboratory of Immune Response and Immunotherapy, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China., Zhu Z; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China., He Q; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China., Xu W; State Key Laboratory of Immune Response and Immunotherapy, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China., Sun B; State Key Laboratory of Immune Response and Immunotherapy, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Source: MSystems [mSystems] 2026 Mar 24; Vol. 11 (3), pp. e0163025. Date of Electronic Publication: 2026 Feb 09.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101680636 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-5077 (Electronic) Linking ISSN: 23795077 NLM ISO Abbreviation: mSystems Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2379-5077
DOI:10.1128/msystems.01630-25