Early-life sleep disruption in Shank3-deficient rats: A preclinical model for autism-related sleep mechanisms and interventions.

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Title: Early-life sleep disruption in Shank3-deficient rats: A preclinical model for autism-related sleep mechanisms and interventions.
Authors: Qiu MH; Department of Neurobiology, Institute for Basic Research on Aging and Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. mhqiu@shmu.edu.cn.; Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China. mhqiu@shmu.edu.cn., Zhong ZG; Department of Neurobiology, Institute for Basic Research on Aging and Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.; Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China., Song PW; Department of Neurobiology, Institute for Basic Research on Aging and Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China., Tao GJ; Department of Neurobiology, Institute for Basic Research on Aging and Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China., Zhang JT; Department of Neurobiology, Institute for Basic Research on Aging and Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.; Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China., Chen YH; Department of Physiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China., Song TJ; Neuroscience Research Institute, Department of Neurobiology, Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Key Laboratory for Neuroscience (Ministry of Education), Key Laboratory for Neuroscience (Ministry of Health), Autism Research Center, Peking University Health Science Center, Beijing, 100191, China., Qu WM; Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China., Zhang R; Neuroscience Research Institute, Department of Neurobiology, Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Key Laboratory for Neuroscience (Ministry of Education), Key Laboratory for Neuroscience (Ministry of Health), Autism Research Center, Peking University Health Science Center, Beijing, 100191, China., Huang ZL; Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China.; Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.; Joint International Research Laboratory of Sleep, Fudan University, Shanghai, 200032, China.
Source: Translational psychiatry [Transl Psychiatry] 2026 Feb 10; Vol. 16 (1). Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2158-3188
DOI:10.1038/s41398-026-03891-0