Genomic analysis of the genetic background underlying Streptococcus pneumoniae beta-lactam nonsusceptibility in central Vietnam: increased beta-lactam nonsusceptibility and dynamics of the pbp2x gene.

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Title: Genomic analysis of the genetic background underlying Streptococcus pneumoniae beta-lactam nonsusceptibility in central Vietnam: increased beta-lactam nonsusceptibility and dynamics of the pbp2x gene.
Authors: Fujii H; Department of Infection Research, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8102, Japan., Sato M; Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.; Department of Frontier Research and Development, Kazusa DNA Research Institute, Kisarazu, 292-0818, Japan., Nguyen HAT; Department of Bacteriology, National Institute of Hygiene and Epidemiology, Hanoi, 100000, Vietnam., Vu HTT; Department of Bacteriology, National Institute of Hygiene and Epidemiology, Hanoi, 100000, Vietnam., Kakiuchi S; Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.; Infection Control and Education Center, Nagasaki University Hospital, Nagasaki, 852-8501, Japan., Dhoubhadel BG; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, 852-8523, Japan., Nakamura S; Department of Infection Metagenomics, Bioinformatics Center, Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan., Motooka D; Department of Infection Metagenomics, Bioinformatics Center, Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan., Ogura Y; Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.; Division of Microbiology, Department of Infectious Medicine, Kurume University School of Medicine, Kurume, 830-0011, Japan., Nakano S; Antimicrobial Resistance Research Center, Japan Institute for Health Security, National Institute of Infectious Diseases, Tokyo, 162-0052, Japan., Parry CM; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, 852-8523, Japan.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, OX3 7LG, UK., Morimoto K; Department of Infection Research, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8102, Japan.; Department of Respiratory Infections, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan., Yoshida LM; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, 852-8523, Japan.; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan., Anh DD; Department of Bacteriology, National Institute of Hygiene and Epidemiology, Hanoi, 100000, Vietnam., Hayashi T; Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan., Iida T; Department of Infection Metagenomics, Bioinformatics Center, Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan.; Department of Bacterial Infections, Research Center for Infectious Disease Control, Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan., Ariyoshi K; Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan. kari@nagasaki-u.ac.jp.; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, 852-8523, Japan. kari@nagasaki-u.ac.jp.
Source: Tropical medicine and health [Trop Med Health] 2026 Feb 10; Vol. 54 (1). Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: Japan NLM ID: 101215093 Publication Model: Electronic Cited Medium: Print ISSN: 1348-8945 (Print) Linking ISSN: 13488945 NLM ISO Abbreviation: Trop Med Health Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1348-8945
DOI:10.1186/s41182-025-00889-0