Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer's disease models.
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| Title: | Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer's disease models. |
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| Authors: | Rao NR; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Santiago-Marrero I; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., DeGulis O; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Nomura T; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Goyal K; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Lee S; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Hark TJ; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Dynes JC; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Dexter EX; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Dulewicz M; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, 405 30 Mölndal, Sweden., Ge J; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, 405 30 Mölndal, Sweden., Upadhyay A; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Fornasiero EF; Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, 37075 Göttingen, Germany.; Department of Life Sciences, University of Trieste, 34127 Trieste, Italy., Vassar R; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Hanrieder J; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, 405 30 Mölndal, Sweden.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, WC1N 3BG London, UK., Contractor A; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Savas JN; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2026 Feb 11; Vol. 18 (836), pp. eadp3984. Date of Electronic Publication: 2026 Feb 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adp3984 |
