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Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer's disease models.

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Title: Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer's disease models.
Authors: Rao NR; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Santiago-Marrero I; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., DeGulis O; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Nomura T; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Goyal K; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Lee S; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Hark TJ; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Dynes JC; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Dexter EX; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Dulewicz M; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, 405 30 Mölndal, Sweden., Ge J; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, 405 30 Mölndal, Sweden., Upadhyay A; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Fornasiero EF; Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, 37075 Göttingen, Germany.; Department of Life Sciences, University of Trieste, 34127 Trieste, Italy., Vassar R; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Hanrieder J; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, 405 30 Mölndal, Sweden.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, WC1N 3BG London, UK., Contractor A; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Savas JN; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Feb 11; Vol. 18 (836), pp. eadp3984. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer's disease models.
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  Data: <searchLink fieldCode="AU" term="%22Rao+NR%22">Rao NR</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Santiago-Marrero+I%22">Santiago-Marrero I</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22DeGulis+O%22">DeGulis O</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Nomura+T%22">Nomura T</searchLink>; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Goyal+K%22">Goyal K</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Hark+TJ%22">Hark TJ</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Dynes+JC%22">Dynes JC</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Dexter+EX%22">Dexter EX</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Dulewicz+M%22">Dulewicz M</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, 405 30 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Ge+J%22">Ge J</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, 405 30 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Upadhyay+A%22">Upadhyay A</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Fornasiero+EF%22">Fornasiero EF</searchLink>; Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, 37075 Göttingen, Germany.; Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Vassar+R%22">Vassar R</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Hanrieder+J%22">Hanrieder J</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, 405 30 Mölndal, Sweden.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, WC1N 3BG London, UK.<br /><searchLink fieldCode="AU" term="%22Contractor+A%22">Contractor A</searchLink>; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Savas+JN%22">Savas JN</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Feb 11; Vol. 18 (836), pp. eadp3984. <i>Date of Electronic Publication: </i>2026 Feb 11.
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