STIM1-containing contact sites promote direct calcium flux from the endoplasmic reticulum to mitochondria.

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Title: STIM1-containing contact sites promote direct calcium flux from the endoplasmic reticulum to mitochondria.
Authors: Orantos-Aguilera Y; Department of Biochemistry and Molecular Biology, School of Life Sciences, Universidad de Extremadura, Badajoz, Spain.; Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, Badajoz, Spain., Sanchez-Lopez I; Department of Biochemistry and Molecular Biology, School of Life Sciences, Universidad de Extremadura, Badajoz, Spain.; Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, Badajoz, Spain., Pascual-Caro C; Department of Biochemistry and Molecular Biology, School of Life Sciences, Universidad de Extremadura, Badajoz, Spain.; Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, Badajoz, Spain.; Paris Brain Institute (ICM), Sorbonne University, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, France., Gómez-Suaga P; Department of Biochemistry and Molecular Biology, School of Nursing and Occupational Therapy, Universidad de Extremadura, Cáceres, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases, Instituto de Salud Carlos III (CIBER-CIBERNED-ISCIII), Madrid, Spain.; Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Spain., Area-Gomez E; Department of Biomedicine, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain., Pozo-Guisado E; Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, Badajoz, Spain.; Department of Cell Biology, School of Medicine, Universidad de Extremadura, Badajoz, Spain., Montesinos J; Department of Biomedicine, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain. jorge.montesinos@cib.csic.es., Martin-Romero FJ; Department of Biochemistry and Molecular Biology, School of Life Sciences, Universidad de Extremadura, Badajoz, Spain. fjmartin@unex.es.; Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, Badajoz, Spain. fjmartin@unex.es.
Source: The EMBO journal [EMBO J] 2026 Mar; Vol. 45 (5), pp. 1760-1793. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-026-00700-8