Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation.
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| Title: | Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation. |
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| Authors: | El-Brolosy MA; Harvard Society of Fellows, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Oak A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Hoang AT; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Damergi Y; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Fischer A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Saunders RA; Harvard Society of Fellows, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Luo J; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Balabaki A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Guez J; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Whitfield TW; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Goldman SR; Nascent Transcriptomics Core, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Latifkar A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Lu YR; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Stainier DYR; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Karczewski KJ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Corradin O; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Weissman JS; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. |
| Source: | Science (New York, N.Y.) [Science] 2026 Feb 12; Vol. 391 (6786), pp. eaea1272. Date of Electronic Publication: 2026 Feb 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.aea1272 |
